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Longitudinal qualitative assessment of meaningful symptoms and relevance of WATCH-PD digital measures for people with early Parkinson's.
J Neurol
January 2025
Center for Health + Technology, University of Rochester Medical Center, Rochester, NY, USA.
Background: Longitudinal qualitative data on what matters to people with Parkinson's disease are lacking and needed to guide patient-centered clinical care and development of outcome measures.
Objective: To evaluate change over time in symptoms, impacts, and relevance of digital measures to monitor disease progression in early Parkinson's.
Methods: In-depth, online symptom mapping interviews were conducted with 33 people with early Parkinson's at baseline and 1 year later to evaluate (A) symptoms, (B) impacts, and (C) relevance of digital measures to monitor personally relevant symptoms.
Content Validity of the Friedreich Ataxia Rating Scale in Patients with Spinocerebellar Ataxia.
Neurol Ther
January 2025
Biohaven Pharmaceuticals, Inc., 215 Church Street, New Haven, CT, 06510, USA.
Introduction: The Friedreich Ataxia Rating Scale-Activities of Daily Living (FARS-ADL) is a validated and highly utilized measure for evaluating patients with Friedreich Ataxia. While construct validity of FARS-ADL has been shown for spinocerebellar ataxia (SCA), content validity has not been established.
Methods: Individuals with SCA1 or SCA3 (n = 7) and healthcare professionals (HCPs) with SCA expertise (n = 8) participated in qualitative interviews evaluating the relevance, clarity, and clinical meaningfulness of FARS-ADL for assessment of individuals with SCA.
Using the Regression Slope of Training Loss to Optimize Chest X-ray Generation in Deep Convolutional Generative Adversarial Networks.
Cureus
January 2025
Department of Critical Care Medicine, Jen Ho Hospital, Show Chwan Health Care System, Changhua, TWN.
Diffusion models, variational autoencoders, and generative adversarial networks (GANs) are three common types of generative artificial intelligence models for image generation. Among these, GANs are the most frequently used for medical image generation and are often employed for data augmentation in various studies. However, due to the adversarial nature of GANs, where the generator and discriminator compete against each other, the training process can sometimes end with the model unable to generate meaningful images or even producing noise.
View Article and Find Full Text PDFInhaled alpha-1 antitrypsin (AAT) restores lower respiratory tract protease-antiprotease homoeostasis and reduces inflammation in AAT-deficient individuals: a randomised phase 2 study.
ERJ Open Res
January 2025
Kamada Ltd., Rehovot, Israel.
Background: Alpha-1 antitrypsin (AAT)-deficient individuals have a greater risk for developing COPD than individuals with normal AAT levels.
Methods: This was a double-blind, randomised, parallel group, placebo-controlled trial to examine the safety and tolerability of "Kamada-AAT for Inhalation" (inhaled AAT) in subjects with AAT deficiency, and to explore its effect on AAT and biomarkers in the lung epithelial lining fluid (ELF). 36 patients with severe AAT deficiency were randomised 2:1 to receive 80 mg or 160 mg inhaled AAT or placebo once daily for 12 weeks.
Revisiting the drivers of electricity consumption in designated Sub-Saharan African regions: Unraveling the role of education.
Heliyon
January 2025
Department of Statistics and Actuarial Science, Kwame Nkrumah University of Science and Technology, Ghana.
It has been established that steady supply of energy to various sectors of the economy is critical for societal growth and development. According to recent figures, barely one-third of the whole population in Sub-Saharan Africa has access to electricity, making the region the poorest in the world in terms of access to electrical power today. This stands in stark contrast to the vast energy resources that could be utilized to provide the necessary energy.
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