AI Article Synopsis
- A β-carbonic anhydrase (CA) from the fungal pathogen Malassezia globosa, identified as MG-CA, shows strong activity in converting CO2 and is effectively inhibited by various sulfonamides.
- Sulfonamides not only inhibited MG-CA in lab studies but also reduced the growth of multiple Malassezia species, highlighting their potential as antifungal agents.
- Results from mouse tests indicated that sulfonamide treatment resulted in damaged fungal structures, suggesting MG-CA as a promising target for developing new antidandruff treatments.
Article Abstract
A β-carbonic anhydrase (CA, EC 4.2.1.1) from the fungal pathogen Malassezia globosa has been cloned, characterized, and studied for its inhibition with sulfonamides. This enzyme, designated MG-CA, has significant catalytic activity in the CO(2) hydration reaction and was inhibited by sulfonamides, sulfamates, and sulfamides with K(I) in the nanomolar to micromolar range. Several sulfonamides have also been investigated for the inhibition of growth of M. globosa, M. dermatis, M. pachydermatic, and M. furfur in cultures, whereas a mouse model of dandruff showed that treatment with sulfonamides led to fragmented fungal hyphae, as for the treatment with ketoconazole, a clinically used antifungal agent. These data prompt us to propose MG-CA as a new antidandruff drug target.
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| http://dx.doi.org/10.1021/jm300203r | DOI Listing |
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