AI Article Synopsis
- The dehydrogenative β'-functionalization process efficiently modifies α-substituted β-keto esters using indoles, achieving high regioselectivity and good yield.
- The reaction occurs under mild conditions with palladium as a catalyst at room temperature, utilizing different oxidants.
- Two mechanisms are proposed that explain the role of indole in the reaction, either entering late or early in the process.
Article Abstract
The dehydrogenative β'-functionalization of α-substituted β-keto esters with indoles proceeds with high regioselectivities (C3-selective for the indole partner and β'-selective for the β-keto ester) and good yields under mild palladium catalysis at room temperature with a variety of oxidants. Two possible mechanisms involving either late or early involvement of indole are presented.
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| http://dx.doi.org/10.1021/ja300684r | DOI Listing |
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