AI Article Synopsis
- The study evaluates the use of octreotide in 21 pediatric patients suffering from various gastrointestinal disorders, focusing on its effectiveness and adverse events.
- Octreotide significantly reduced blood transfusion needs in cases of gastrointestinal bleeding and led to resolution of conditions like pancreatic pseudocysts, chylothorax, and chronic diarrhea in several patients.
- While octreotide proves beneficial for pediatric patients, some serious side effects were observed, highlighting the need for careful monitoring during treatment.
Article Abstract
Background/aim: We report our experience with the use of octreotide as primary or adjunctive therapy in children with various gastrointestinal disorders.
Patients And Methods: A pharmacy database identified patients who received octreotide for gastrointestinal diseases. Indications for octreotide use, dosing, effectiveness, and adverse events were evaluated by chart review.
Results: A total of 21 patients (12 males), aged 1 month to 13 years, were evaluated. Eleven received octreotide for massive gastrointestinal bleeding caused by portal hypertension-induced lesions (n=7), typhlitis (1), Meckel's diverticulum (1), and indefinite source (2). Blood transfusion requirements were reduced from 23 ± 9 mL/kg (mean ± SD) to 8 ± 15 mL/kg (P<0.01). Four patients with pancreatic pseudocyst and/or ascites received octreotide over 14.0 ± 5.7 days in 2 patients. In 3 children, pancreatic pseudocyst resolved in 12 ± 2 days and pancreatic ascites resolved in 7 days in 2. Three patients with chylothorax received octreotide for 14 ± 7 days with complete resolution in each. Two infants with chronic diarrhea received octreotide over 11 ± 4.2 months. Stool output decreased from 85 ± 21 mL/kg/day to 28 ± 18 mL/kg/day, 3 months after initiation of octreotide. The child with dumping syndrome responded to octreotide in a week. Adverse events developed in 4 patients: Q-T interval prolongation and ventricular fibrillation, hyperglycemia, growth hormone deficiency, and hypertension.
Conclusion: Octreotide provides a valuable addition to the therapeutic armamentum of the pediatric gastroenterologist for a wide variety of disorders. Serious adverse events may occur and patients must be closely monitored.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326982 | PMC |
| http://dx.doi.org/10.4103/1319-3767.93807 | DOI Listing |
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