Introduction: In high tibial osteotomies (HTO) the correction needs to be precise and intra-operative assessment is essential. The purpose of this study was to evaluate the use of the intra-operative clinical mechanical axis measurement and compare it to the post-operative weight bearing situation on standing whole leg radiographs (WLR). Secondly, we evaluated the preoperative planned wedge size and compared it to the final results in 27 HTOs.
Methods: The mechanical axis deviation (MAD), expressed as a percentage of the tibial width (0% is medial edge, 100% is lateral edge) and the hip-knee-ankle angle (HKA) were calculated and analyzed. Preoperative planning was done by projecting the desired mechanical axis on the lateral tibial spine on the WLR and subsequently calculating the necessary correction angle. A 3° valgus correction was desired.
Results: The results showed a preoperative standing MAD of 26.6%, or about halfway the medial tibial plateau. The MAD was corrected to 57.0% intra-operative, meaning a slight valgus. On the postoperative standing WLR, the MAD had shifted significantly to 62.0% (95% CI=-9.2 to -2.7; p<0.01) compared to the intra-operative 57.0% axis. The HKA angle changed 8.2° from 5.1° varus preoperative to 3.1° valgus postoperative.
Conclusion: When aiming the mechanical axis at the lateral tibial spine, a slight undercorrection was introduced, but due to a valgus shift while weight bearing, a satisfying final outcome of 3° valgus average was achieved. Preoperative calculation of the wedge size remains important for surgical planning, but it does not always correspond to the actual used wedge size.
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http://dx.doi.org/10.1016/j.knee.2012.02.003 | DOI Listing |
Purpose Of The Study: Intraarticular fractures of the distal femur rank among the most severe musculoskeletal injuries. Various treatment options, such as plate osteosynthesis or retrograde nailing, can be employed. This study aims to evaluate the clinical outcomes and complications of intraarticular distal femoral fractures treated with retrograde femoral nail, with particular emphasis on C3 fractures.
View Article and Find Full Text PDFActa Chir Orthop Traumatol Cech
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Klinika dětské chirurgie, ortopedie a traumatologie Fakultní nemocnice Brno.
Purpose Of The Study: Temporary hemiepiphyseodesis using figure-eight plates is currently one of the main surgical techniques to correct axial deformities of lower limbs in paediatric patients. Comprehensive analysis, correct indication and monitoring of treatment are the basic prerequisites for successful therapy. The aim of the study was to analyse parameters that could become an alternative to standard parameters used nowadays, namely the inserted screw angle (SA), and a new parameter - condylar ratio (CR).
View Article and Find Full Text PDFInt J Biol Sci
January 2025
Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai, China.
Skin fibrotic diseases are characterized by abnormal fibroblast function and excessive deposition of extracellular matrix. Our previous single-cell sequencing results identified an enriched fibroblast subcluster in skin fibrotic tissues that highly expresses the actin cross-linking cytoskeletal protein Transgelin (TAGLN), which bridges the mechanical environment of tissues and cellular metabolism. Therefore, we aimed to investigate the role of TAGLN in the pathogenesis of skin fibrosis.
View Article and Find Full Text PDFBiomark Res
January 2025
Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Background: Although immunotherapy has achieved great progress in advanced triple-negative breast cancer (TNBC), there are still numerous patients who do not benefit from immunotherapy. Therefore, identification of the key molecule that induces immune escape and clarification of its specific mechanism in TNBC are urgently needed.
Methods: In this research, single cell sequencing and bulk sequencing were conducted for biomarker screening.
Acta Pharmacol Sin
January 2025
Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, State Key Laboratory of Cardiovascular Diseases, NHC Key Laboratory of Ischemic Heart Diseases, and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China.
Pressure overload induces pathological cardiac remodeling, including cardiac hypertrophy and fibrosis, resulting in cardiac dysfunction or heart failure. Recently, we observed that the low-density lipoprotein receptor-related protein 6 (LRP6), has shown potential in enhancing cardiac function by mitigating cardiac fibrosis in a mouse model subjected to pressure overload. In this study, we investigated the role of LRP6 as a potential modulator of pressure overload-induced cardiac hypertrophy and elucidated the underlying molecular mechanisms.
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