Objective: The aim of the study was to evaluate the microbiologic changes that occurred in the nasal and ocular mucosa before and after surgery in patients who had undergone septoplasty.
Design Setting: Fifty-five patients who applied to our clinic with septal deviation were included in the study.
Methods: Before and after the operation, samples were taken from the ocular and inner nasal mucosa for cultures and direct microscopic evaluation and the microbiologic changes were compared.
Main Outcome Measures: The results of ocular preoperative cultures were different from the results of postoperative cultures.
Results: The most frequent microorganisms in all pre- and postoperative ocular and nasal cultures were similar; coagulase-negative Staphylococcus, Staphylococcus aureus, and Diphtheroid spp were dominant. Following septoplasty, the rate of determining microorganisms in the eye in both microscopic evaluation and cultures had increased. In the postoperative period, the rate of growing S. aureus increased in ocular cultures (p < .01) while remaining the same in nasal cultures.
Conclusions: These results suggest that ocular flora can indeed change following septoplasty; however, the risk of ocular infection is not increased. This is the first study to investigate the risk of ocular infection in addition to local nasal infection after septoplasty.
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Ophthalmic Physiol Opt
January 2025
Robert O Curle Ophthalmology Suite, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, UK.
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Department of Ophthalmology, Faculty of Medicine, University of Medicine and Pharmacy "Grigore T. Popa", University Street, No. 16, 700115 Iasi, Romania.
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January 2025
Scotland's Rural College, Roslin Institute Building, Easter Bush Campus, Midlothian EH25 9RG, UK.
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Introduction: The rapid progress in polymer science has designed innovative materials for biomedical applications. In the case of drug design, for each new therapeutic agent, a drug delivery system (DDS) is required to improve its pharmacokinetic and pharmacodynamic parameters. Therefore, significant research has been carried out to develop drug delivery (DD) carriers for these new therapeutic agents.
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January 2025
Department of Ophthalmology, Faculty of Medicine, Hitit University, Çorum, Turkey.
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