[Effect of streptozotocin-induced diabetes and transient global brain ischemia on apoptosis in the thymus of rats].

The influence of incomplete global ischemia-reperfusion of the brain on the activity of pro- and antiapoptotic processes in the thymocytes by the intensity of p53 and Bcl-2 - proteins expressions has been investigated. It has been shown that in the cortical zone of thymus of rats with a four-month diabetes, as well as in the control rats and rats with diabetes mellitus after brain ischemia, the antiapoptotic processes are dominated. In the medullar zone of the gland in rats with diabetes, complicated and uncomplicated with brain ischemia-reperfusion the antiapoptotic mechanisms predominate too, but to a lesser extent than in the cortical zone.