Healthcare reform will impact hospital consolidation in three key areas: Payment rates will decrease, indirectly encouraging consolidation by forcing hospitals to find new ways to reduce costs and increase negotiating clout with suppliers and payers. The cost of doing business will increase as hospitals spend more on compliance, technology, and physician employment. The ACO model will encourage hospital network formation by rewarding integrated healthcare systems that can reduce costs and improve quality.
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J Biomol Struct Dyn
March 2025
School of Mechatronic Engineering and automation, Shanghai University, Shanghai, China.
Prediction of protein-ligand interactions is critical for drug discovery and repositioning. Traditional prediction methods are computationally intensive and limited in modeling structural changes. In contrast, data-driven deep learning methods significantly reduce computational costs and offer a more efficient approach for drug discovery.
View Article and Find Full Text PDFNanomaterials (Basel)
March 2025
Grupo de Investigación de Nanotecnología Aplicada para Biorremediación Ambiental, Energía, Biomedicina y Agricultura (NANOTECH), Facultad de Ciencias Físicas, Universidad Nacional Mayor de San Marcos, Av. Venezuela Cdra 34 S/N, Ciudad Universitaria, Lima 15081, Peru.
The use of natural organic extracts in nanoparticle synthesis can reduce environmental impacts and reagent costs. With that purpose in mind, a novel biosynthesis procedure for the formation of magnetic iron-oxide nanoparticles (IONPs) using extract in an aqueous medium has been systematically carried out. First, the biosynthesis was optimized for various extract concentrations, prepared by decoction and infusion methods, and yielded IONPs with sizes from 4 to 9 nm.
View Article and Find Full Text PDFAnim Biotechnol
December 2025
Faculty of Science, Dookie College, The University of Melbourne, Melbourne, Australia.
This study aimed to 1) Establish relationships between feed conversion efficiency (FCE; live weight gain/intake) and several biomarkers in pigs using blood and hair samples, and 2) Investigate the relative FCE performance of pigs from maternal vs. terminal genetic lines fed high vs. low energy diets.
View Article and Find Full Text PDFEndokrynol Pol
March 2025
Department of Endocrinology and Internal Medicine, Medical University Wrocław, Wroclaw, Poland.
Introduction: The analysis of the costs associated with treating acromegaly and its complications is important in planning diagnostics and treatment for a single patient, as well as in establishing the standard of care for the entire population of acromegaly patients. Data on the actual costs of treating patients with acromegaly in Poland are limited.
Aims Of The Study: To determine the direct cost (hospital stays, diagnostic imaging, surgical treatment, pharmacotherapy, tumour irradiation) of treating patients with acromegaly and its complications, assessing the relationship between acromegaly treatment costs and the radical nature of the treatment.
J Opioid Manag
March 2025
SA Pharmacy, Government of South Australia, Adelaide, Australia. ORCID: https://orcid.org/0000-0003-4786-022X.
Introduction: Chronic pain is a leading cause of chronic disease in Australia, with a 2020 report indicating that one in five Australians aged over 45 experience chronic pain. The high prevalence of chronic pain accounts for significant healthcare utilization and associated costs, with the economic impact of chronic pain estimated to be AUD$139 billion in 2018.
Case Presentations: This paper uses two exemplar cases to demonstrate inadequacies within the current systems supporting those with chronic pain and the associated impacts these inadequacies have on patient outcomes and healthcare costs.
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