The red raspberry extract possesses potent antioxidant capacity and anticancerous activity in vitro and in vivo. The objective of this study was to determine whether red raspberry extract affected the cell cycle, angiogenesis, and apoptosis in hepatic lesion tissues from a rat model induced by diethylnitrosamine (DEN) as well as changes of serum proteomics. Rats were treated with red raspberry extract (0.75, 1.5, or 3.0 g/kg of body weight) by gavage starting 2 h after DEN administration and continued for 20 wk. Red raspberry extract inhibited cell proliferation, vascular endothelial growth factor VEGF expression, and induced apoptosis in the hepatic lesion tissues. In addition, 2 protein peaks (2597.93 and 4513.88 m/z) were identified to differentially express in the 3.0 g/kg body weight and positive control groups by serum proteomics. These results suggest that a dietary supplement with red raspberry effectively protects against chemically induced hepatic lesions in rats.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1750-3841.2011.02373.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Color, Structure, and Thermal Stability of Alginate Films with Raspberry and/or Black Currant Seed Oils.
Molecules
January 2025
Department of Analytical Chemistry and Applied Spectroscopy, Faculty of Chemistry, Nicolaus Copernicus University in Toruń, Gagarina 7, 87-100 Toruń, Poland.
In this study, biodegradable and active films based on sodium alginate incorporated with different concentrations of oils (25% and 50%) from fruit seeds were developed for potential applications in food packaging. The ultraviolet and visible (UV-VIS) spectra of raspberry seed oil (RSO) and black currant seed oil (BCSO) indicated differences in bioactive compounds, such as tocopherols, phenolic compounds, carotenoids, chlorophyll, and oxidative status (amounts of dienes, trienes, and tetraenes) of active components added to alginate films. The study encompassed the color, structure, and thermal stability analysis of sodium alginate films incorporated with RSO and BCSO and their mixtures.
View Article and Find Full Text PDFAssembly and comparative analysis of the complete mitochondrial genome of red raspberry (Rubus idaeus L.) revealing repeat-mediated recombination and gene transfer.
BMC Plant Biol
January 2025
CAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, Hubei, 430074, China.
Background: Red raspberry (Rubus idaeus L.) is a renowned fruit plant with significant medicinal value. Its nuclear genome and chloroplast genome (plastome) have been reported, while there is a lack of genetic information on its mitogenome.
View Article and Find Full Text PDFBiostimulants with glycine betaine or kelp extract alleviate heat stress in red raspberry (Rubus idaeus).
Sci Rep
January 2025
Department of Horticulture, Washington State University Northwestern Washington Research and Extension Center, Mount Vernon, WA, 98221, USA.
Biostimulants are an emerging and innovative class of products that may mitigate the adverse effects of extreme heat, but research on their efficacy in fruit crops is limited. This study addressed this knowledge gap by evaluating the performance of three biostimulants, FRUIT ARMOR™, Optysil®, and KelpXpress™ [active ingredients glycine betaine, silicon, and kelp (Ascophyllum nodosum) extract, respectively] applied to three raspberry genotypes exposed to high temperatures (T ≥ 35 °C/day) inside a glasshouse. 'Meeker' consistently maintained high chlorophyll fluorescence (F/F) and photosynthesis under control and biostimulant treatments.
View Article and Find Full Text PDFAsymmetric Microgels with Tunable Morphologies by Assembly-Guided Polymerization of Liquid Crystalline Monomers.
Small
January 2025
Institute of Technical and Macromolecular Chemistry, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany.
Article Synopsis
- Understanding microgel morphology is key for enhancing their functions in various applications, but traditional methods are often limited and low in efficiency.
- A new bottom-up approach is introduced for creating unique non-spherical microgels from N-vinylcaprolactam using a specific liquid crystalline comonomer, allowing for more diverse shapes like multilobe, dumbbell, and raspberry forms.
- By manipulating factors like LCM addition time, temperature, and solvent ratios, researchers can fine-tune microgel shapes, which are characterized using microscopy and light scattering techniques, and they show potential in solubilizing hydrophobic compounds like Nile Red.
A comprehensive profiling of phenolic compounds and antioxidant activities of 24 varieties of red raspberry cultivated in Northeast China.
J Food Sci
January 2025
College of Life Science, Northeast Forestry University, Harbin, China.
Red raspberries, valued for their nutrients and bioactive compounds, have broad uses in processing and healthy products. However, limited comprehensive research focused on the comparison of phenolic compounds of red raspberry, especially species cultivated in Northeast China, has been reported. This study aimed to conduct a thorough investigation of 24 red raspberry varieties in Northeast China for the first time, evaluating their phenolic compounds and antioxidant capacities.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!