The paper provides literature data concerning the role of heredity, anatomico-physiological peculiarities which contribute to the chronic pyelonephritis formation in the childhood. The conditions of the infectious-inflammatory process development in the urinary tract are specified and some reasons of its chronization are mentioned. The peculiarities of the immunological reaction are analysed, as well as the role of nonimmune mechanisms, such as the lipid peroxidation process during the pyelonephritis development in the childhood.

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