Hospitalizations for some health conditions can be reduced by timely primary care with appropriate quality, especially in children. This study analyzed the trend in hospitalizations in children under five years of age in Piauí State, Brazil, from 2000 to 2010, according to groups of causes (ICD-10) and hospital admissions in 2010, based on the Brazilian List of Hospitalizations for Primary Care-Sensitive Conditions. The objectives were to identify changes in the hospital morbidity profile and to discuss their relationship to expansion of the Family Health Strategy (FHS) in the State. Piauí showed the highest proportional expansion of the FHS in Brazil, reaching an estimated coverage of 97.2% in 2010. From 2000 to 2010, there was a reduction in the hospitalization frequency and rates in children under five years, but the proportion of hospitalizations in the leading groups of causes persisted or increased during the decade. In 2010, 60% of hospitalizations in children under five years were for causes that are sensitive to primary care, especially infectious gastroenteritis, respiratory infections, and asthma.
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