64 patients with lung tuberculosis were operated on after chemotherapy course using regimens I and III. 69 patients were operated on after the treatment by DOTS/PLUS protocol. The obtained operative material was bacteriologically tested. Bacterial growth in samples of patients treated with DOTS/PLUS protocol caused by multydrug resistance of mycobacteria. The noncoinsidence of the drug resistance spectrum in sputum and resected samples was registered in 33% of patients treated by DOTS/ PLUS protocol and 25% of patients, treated by using regimens I and III.
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