Background/purpose: Oral lichen planus is an autoimmune disorder that has posed a challenge in spite of the several treatment modalities available. Here, we have proposed yet another treatment modality, photodynamic therapy, for this condition. The aim of the study was to treat patients having symptomatic oral lichen planus with photodynamic therapy with methylene blue as photosensitizer.
Methods: Twenty patients with symptomatic oral lichen planus were included in the study. They were treated with 5% methylene blue mediated photodynamic therapy (light source: Xenon arc lamp, wavelength: 630 ± 5 nm, total dose: 120 J/cm(2) per sitting) in four sessions (1st, 4th, 7th and 15th day). Follow-up was done on second and fourth week after the therapy.
Results: There was significant improvement in signs and symptoms of the lesion at first and second follow-up visits (P-value<0.001).
Conclusion: There was satisfactory reduction in signs and symptoms of oral lichen planus without any side effects. Thus, methylene blue mediated photodynamic therapy seems to be a promising alternative for the control of oral lichen planus.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1600-0781.2012.00647.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Clinical characteristics, management, and malignancy rate of oral lichen planus: a European multicenter study.
J Stomatol Oral Maxillofac Surg
January 2025
Department of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Introduction: Oral lichen planus (OLP) is a chronic inflammatory mucocutaneous condition that includes a spectrum of oral clinical manifestations ranging from mild painless white lesions to painful erosions and ulcers. The purpose of this European multicenter study is to describe the general characteristics of OLP lesions, the clinical and histopathological diagnosis, and the management of OLP at different European Oral Medicine and Maxillofacial Surgery centers, in order to minimize selections biases and provide information about the current trends in the treatment of OLP across Europe.
Materials And Methods: Data and histopathological records of patients with OLP were retrospectives revised and only those patients that fulfilled the diagnostic criteria from the 2016 position paper by American Academy of Oral and Maxillofacial Pathology were included.
Assessment of a Bioimpedance-Based Method for the Diagnosis of Oral Cancer.
Diagnostics (Basel)
December 2024
Department of Oral Medicine, School of Dental Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Oral cancer (OC) is a disease with poor prognosis mainly due to late diagnosis. There is considerable interest in the use and development of rapid, point of care (POC) non-invasive methods that can accelerate the diagnostic process. Bioimpedance (BI) is resistance to the passage of electric currents through tissue that reflects structural changes in the tissue.
View Article and Find Full Text PDFThere are no good evidence-based recommendations for any systemic treatment of erosive lichen planus (ELP). Extracorporeal photopheresis (ECP) may be an effective therapy for recalcitrant forms of the disease. We report 3 patients with severe ELP treated with ECP.
View Article and Find Full Text PDFMAIT cells modulating the oral lichen planus immune microenvironment: a cellular crosstalk perspective.
Inflamm Res
January 2025
Departments of Oral Medicine, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, Guangdong Province, China.
Mucosal-associated invariant T (MAIT) cells, a type of T lymphocytes with innate-like characteristics, are crucial in bridging innate and adaptive immunity. When activated, MAIT cells release various inflammatory molecules and swiftly respond to antigens. Notably, numerous studies highlight the significant impact of MAIT cells on tumors and various immune disorders by influencing the immune microenvironment.
View Article and Find Full Text PDFIs There a Correlation Between Quality of Life and Salivary Interleukin-6 in Patients With Oral Lichen Planus or Burning Mouth Syndrome?
Oral Dis
January 2025
Department of Medical Laboratory Diagnostics, University Hospital of Split, Split, Croatia.
Objectives: The aim of our study was to compare the salivary interleukin-6 (IL-6) concentration and the quality of life (QoL) in patients with oral lichen planus (OLP) or burning mouth syndrome (BMS).
Materials And Methods: A total of 160 subjects participated in the cross-sectional study. The unstimulated whole saliva (UWS) was used as a reference for the determination of salivary IL-6 concentration by enzyme-linked immunosorbent assays (ELISAs).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!