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Drug Development.
Alzheimers Dement
December 2024
University of Kansas Alzheimer's Disease Research Center, Fairway, KS, USA.
Background: Aerobic exercise may positively affect brain health, although relationships with cognitive change are mixed. This likely is due to individual differences in the systemic physiological response to exercise. However, the acute effects of exercise on brain metabolism and biomarker responses are not well characterized in older adults or cognitively impaired individuals.
View Article and Find Full Text PDFDementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
University of Missouri, Columbia, MO, USA.
Background: Despite data showing nutritional interventions high in antioxidant/anti-inflammatory properties (anthocyanin-rich foods such as blueberries/elderberries) may decrease risk of memory loss and cognitive decline, evidence for such effects in mild cognitive impairment (MCI) patients is limited. Therefore, we examined preliminary effects of American elderberry (Sambucus nigra canadensis) juice on cognition and inflammatory markers in MCI patients in a double-blind placebo-controlled trial.
Method: MCI patients (N = 24, M = 76.
Gut-derived lactic acid enhances tryptophan to 5-hydroxytryptamine in regulation of anxiety via .
Gut Microbes
December 2025
MOE/NHC/CAMS Key Lab of Medical Molecular Virology, School of Basic Medical Sciences, & National Clinical Research Center for Aging and Medicine, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
The gut microbiota plays a pivotal role in anxiety regulation through pathways involving neurotransmitter production, immune signaling, and metabolic interactions. Among these, gut-derived serotonin (5-hydroxytryptamine, 5-HT), synthesized from tryptophan metabolism, has been identified as a key mediator. However, it remains unclear whether specific microbial factors regulate tryptophan metabolism to influence 5-HT production and anxiety regulation.
View Article and Find Full Text PDFEffects of the music tempo during walking exercise on heart rate variation, lactic acid, and aerobic variables in male college students.
J Exerc Rehabil
December 2024
Department of Kinesiology, College of Natural Science, Jeju National University, Jeju, Korea.
The purpose of this study is to investigate the effects of music tempo on heart rate (HR), HR variability (HRV), lactate levels, and aerobic capacity during walking exercise in male college students. Ten male college students randomly participated in three experiments using various music tempos on a treadmill device to prevent data contamination between measurements by allowing a 2-week interval. Walking exercise was performed at a moderate intensity of 60%-70% maximum HR for 30 min, with participants divided into three groups based on music tempo: exercise group with fast tempo music (ExF, 120-160 bpm), exercise group with slow tempo music (ExS, 60-70 bpm), and exercise group without music (Ex).
View Article and Find Full Text PDFTiming of adjunctive vasopressin initiation for septic shock patients and hospital mortality: A multicentre observational study.
Crit Care Resusc
December 2024
Department of Intensive Care, Austin Hospital, 145 Studley Road, Heidelberg, Victoria, Australia.
Objective: The optimal timing of vasopressin initiation as an adjunctive vasopressor remains unclear. We aimed to study the association between the timing of vasopressin commencement, pre-specified physiological parameters, and hospital mortality.
Design: We conducted a multicentre, retrospective, observational study.
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