Nano-scale silver particle stabilized by gelatin protein was prepared through the reduction of aqueous silver nitrate solution by sodium borohydride. Gelatin concentration was varied against a fixed concentration of silver nitrate to optimize the gelatin to metal ratio. Gelatin-protected Ag-nanoparticle was characterized by UV-VIS spectroscopy and transmission electron microscopy (TEM). All the samples exhibited similar yellow color with a characteristic plasmonic band of silver nanoparticles at 412 nm. TEM micrographs also showed the presence of nanoscale silver particles of approximately 3.9 nm. Since silver has strong bactericidal properties and at the same time relatively less toxic to human cell, silver in various forms is ideally suited for a wide range of applications in consumer, industrial and medical products The antimicrobial properties of gelatin-silver nanocomposites were tested by 'cup-plate zone of inhibition' method. The nanocomposites exhibited significant antibacterial and antifungal activity.
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http://dx.doi.org/10.1166/jnn.2011.5109 | DOI Listing |
Langmuir
January 2025
Electroplating Metal Finishing Division, CSIR-Central Electrochemical Research Institute, Karaikudi, 630003 TamilNadu, India.
We report the in situ synthesis of silver-containing polyisocyanurate (Ag-PI) gels via the self-polymerization of isocyanate-containing organic molecules (Desmodur N75) catalyzed by silver nitrate (AgNO) in ,'-dimethylformamide, which acts as both the solvent and reducing agent. Fourier transform infrared spectroscopy and X-ray diffraction confirmed the formation of polyisocyanurate and metallic silver nanoparticles. Gelation occurred in 30 min at 30 °C for Ag-PI, compared to 24 h for the uncatalyzed system, demonstrating AgNO's catalytic role.
View Article and Find Full Text PDFJ Med Microbiol
January 2025
Medical Mycology Laboratory, Department of Clinical Analysis and Biomedicine, State University of Maring, Colombo Avenue, 5790, Maring, PR, Brazil.
Fungal infections caused by yeast have increased in recent decades, becoming a major threat to public health. Antifungal therapy represents a challenging problem because, in addition to presenting many side effects, fungal resistance has been increasing in recent years. As a result, the search for new therapeutic agents has advanced with the use of new technologies such as nanoparticles (NPs).
View Article and Find Full Text PDFRSC Adv
January 2025
Institute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig Beethovenstr. 55 38106 Braunschweig Germany
The antimicrobial properties of silver and silver complexes have been known in medicine since ancient times. However, limitations in stability and solubility have impaired medicinal chemistry and drug development research. With the advent of N-heterocyclic carbenes (NHC) as ligands, the development of synthesis methods for organometallic silver species of the type (NHC)AgX (where X = halide) has brought significant improvements, and the class of antimicrobial silver NHC complexes has emerged.
View Article and Find Full Text PDFCureus
December 2024
Pediatric Surgery, Combined Military Hospital (CMH) Lahore Medical College, Institute of Dentistry, Lahore, PAK.
An umbilical granuloma (UG) is one of the most common umbilical anomalies seen in infants, mostly due to delayed cord separation. It is usually treated with silver nitrate; however, topical application of silver nitrate can cause chemical burns, creating concern among parents. We present a similar case in a two-month-old baby boy with a giant UG, which was treated with topical silver nitrate application, producing significant chemical burns around the umbilicus and on the anterior abdominal wall.
View Article and Find Full Text PDFStomatologiia (Mosk)
January 2025
Central Research Institute of Dentistry and Maxillofacial Surgery, Moscow, Russia.
Objective: Study on the impact of medical wound dressing compositions on reference strains of microorganisms in vitro conditions.
Materials And Methods: The study compared the antimicrobial activity of three types of dressing materials (DM): iodoform gauze bandage, DM with furagin and sodium alginate, DM from hydrogel with dimexide and silver nitrates. Gauze bandage with chlorhexidine was used as a control.
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