Influence of post-treatment with 75% (v/v) ethanol vapor on the properties of SF/P(LLA-CL) nanofibrous scaffolds.

Int J Mol Sci

College of Materials and Textile Engineering, Jiaxing University, Zhejiang 314001, China.

Published: September 2015

AI Article Synopsis

  • Researchers improved the water-resistant properties of silk fibroin (SF) and SF/P(LLA-CL) blended nanofibrous scaffolds using 75% ethanol vapor post-treatment, which preserved their nanofibrous structure.
  • The treatment led to a structural change in the silk fibroin, transitioning its conformation from a random coil or α-helix to a β-sheet, enhancing its water resistance and mechanical strength.
  • Despite becoming hydrophobic upon treatment, the SF/P(LLA-CL) scaffolds showed superior water absorption compared to pure P(LLA-CL), making this method promising for biomedical applications.

Article Abstract

In order to improve the water-resistant ability of silk fibroin (SF) and SF/P(LLA-CL) blended nanofibrous scaffolds for tissue engineering applications, 75% (v/v) ethanol vapor was used to post-treat electrospun nanofibers. SEM indicated that the treated SF and SF/P(LLA-CL) nanofibrous scaffolds maintained a nanofibrous structure and possessed good water-resistant ability. Characterization of (13)C CP-MAS NMR clarified that 75% (v/v) ethanol vapor could induce SF conformation from random coil or α-helix to β-sheet. Although the water contact showed that treated SF/P(LLA-CL) blended nanofibrous scaffolds were hydrophobic, the water uptake demonstrated that their hydrophilicity was greatly superior to those of pure P(LLA-CL) nanofibrous scaffolds. Furthermore, the treated SF/P(LLA-CL) nanofibrous scaffolds, both in dry state and wet state, could retain good mechanical properties. Therefore, 75% (v/v) ethanol vapor treatment might be an ideal method to treat SF and SF/P(LLA-CL) nanofibrous scaffolds for biomedical applications.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292005PMC
http://dx.doi.org/10.3390/ijms13022036DOI Listing

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