AI Article Synopsis
- The immune system plays a complex role in cancer, with immune-compromised individuals experiencing higher cancer rates, yet inflammation can also drive disease progression.
- Basic immune response measurements in blood aren't very effective for understanding cancer, highlighting the need to study tumor-infiltrating immune cells instead.
- Recent research emphasizes the importance of chemokine expression in tumors, pointing towards the potential for therapies that modify these chemokines to influence the immune environment within tumors.
Article Abstract
The immune system has multiple, complex, and sometimes opposing roles during cancer progression. While immune-compromised individuals have a higher incidence of cancers, inflammation is also associated with increased risk of disease progression. It is becoming apparent that simple measures of immune responses in the blood are of limited use in cancer. Instead, the importance of the exact identity and functional characteristics of tumor-infiltrating immune cells is increasingly recognized. This realization has led to recent studies that have revealed a critical role for chemokine expression in the tumor microenvironment and suggested a therapeutic potential of manipulating intratumoral expression of chemokines to alter the local immune milieu.
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| http://dx.doi.org/10.1007/s12026-012-8288-4 | DOI Listing |
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