Stroke still remains a major healthcare problem. The growing understanding of the mechanism of cell death in ischemia leads to new approaches in stroke treatment. The aim of neuroprotection is to reduce the post-stroke impairment and the overall costs that are accompanied in patients with severe disability. Despite encouraging data from experimental animal models, almost all neuroprotective therapies have, to date, not been established in clinical routine. In this part B of our review on stroke therapies we provide an overview on future candidates in stroke therapy and neuroprotective agents that are under investigation.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.drudis.2012.02.011 | DOI Listing |
Sci Rep
January 2025
Feed the Future Innovation Lab for Collaborative Research on Sustainable Intensification, Kansas State University, Manhattan, KS, 66506, USA.
The increasing frequency of heat stress events due to climate change disrupts all stages of plant growth, significantly reducing yields, especially in crops like mung bean (Vigna radiata (L.) R. Wilczek).
View Article and Find Full Text PDFBiochem Pharmacol
January 2025
School of Bio-Sciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu 632014, India. Electronic address:
Breast cancer (BC) is the most prevalent type of cancer in women worldwide and it is classified into a few distinct molecular subtypes based on the expression of growth factor and hormone receptors. Though significant progress has been achieved in the search for novel medications through traditional and advanced approaches, still we need more efficacious and reliable treatment options to treat different types and stages of BC. Sirtuins (SIRT1-7) a class III histone deacetylase play a major role in combating various cancers including BC.
View Article and Find Full Text PDFChemosphere
January 2025
School of Mechanical Engineering, Korea University of Technology and Education, Cheonan, Chungnam, 31253, Republic of Korea; Advanced Technology Research Centre, Korea University of Technology and Education, Cheonan, Chungnam, 31253, Republic of Korea; Future Convergence Engineering, Korea University of Technology and Education, Cheonan, Chungnam, 31253, Republic of Korea. Electronic address:
In the field of solar steam generation, hydrogels with interfacial evaporation configurations stand as a promising candidate for solar evaporators. Hydrogel-based photothermal materials provide excellent hydration channels for supplying water to an evaporative layer due to their porous structure and hydrophilic nature. This work proposed a facile and in-situ fabrication of sodium alginate hydrogel incorporated with cellulose nanocrystals and polypyrrole as an effective photothermal material.
View Article and Find Full Text PDFMol Plant Microbe Interact
January 2025
ETH Zurich Department of Environmental Systems Science, Plant Pathology Group, Institute of Integrative Biology, Zurich, Zürich, Switzerland.
Adaptation to new climates poses a significant challenge for plant pathogens during range expansion, highlighting the importance of understanding their response to climate to accurately forecast future disease outbreaks. The wheat pathogen is ubiquitous across most wheat production regions distributed across diverse climate zones. We explored the genetic architecture of thermal adaptation using a global collection of 411 strains that were phenotyped across a wide range of temperatures and then included in a genome-wide association study.
View Article and Find Full Text PDFChem Commun (Camb)
January 2025
Institute for Carbon Neutralization Technology, College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, Zhejiang 325035, China.
Single-atom catalysts (SACs) have become the forefront and hotspot in energy storage and conversion research, inheriting the advantages of both homogeneous and heterogeneous catalysts. In particular, carbon-supported SACs (CS-SACs) are excellent candidates for many energy storage and conversion applications, due to their maximum atomic efficiency, unique electronic and coordination structures, and beneficial synergistic effects between active catalytic sites and carbon substrates. In this review, we briefly review the atomic-level regulation strategies for optimizing CS-SACs for energy storage and conversion, including coordination structure control, nonmetallic elemental doping, axial coordination design, and polymetallic active site construction.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!