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DNA spontaneously wrapping around a histone core prefers negative supercoiling: A Brownian dynamics study.
PLoS Comput Biol
January 2025
Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, China.
In eukaryotes, DNA achieves a highly compact structure primarily due to its winding around the histone cores. The nature wrapping of DNA around histone core form a 1.7 left-handed superhelical turns, contributing to negative supercoiling in chromatin.
View Article and Find Full Text PDFUse of β-Blockers in COPD: The Long and Winding Road.
Chest
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Liverpool School of Tropical Medicine, Liverpool, England.
Circular Dichroism and Interlayer Exciton Hall Effect in Transition Metal Dichalcogenides Homobilayers.
Nano Lett
January 2025
School of Physics, State Key Laboratory of Crystal Materials, Shandong University, Jinan 250100, China.
In van der Waals (vdW) architectures of transition metal dichalcogenides (TMDCs), the coupling between interlayer exciton and quantum degrees of freedom opens unprecedented opportunities for excitonic physics. Taking the MoSe homobilayer as representative, we identify that the interlayer registry defines the nature and dynamics of the lowest-energy interlayer exciton. The large layer polarization () is proved, which ensures the formation of layer-resolved interlayer excitons.
View Article and Find Full Text PDFTriplex H-DNA structure: the long and winding road from the discovery to its role in human disease.
NAR Mol Med
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Department of Biology, Tufts University, 200 Boston Ave., Medford, MA 02155, USA.
H-DNA is an intramolecular DNA triplex formed by homopurine/homopyrimidine mirror repeats. Since its discovery, the field has advanced from characterizing the structure to discovering its existence and role . H-DNA interacts with cellular machinery in unique ways, stalling DNA and RNA polymerases and causing genome instability.
View Article and Find Full Text PDFEffects of Hygrothermal Condition on Water Diffusion and Flexural Properties of Carbon-Glass Hybrid Fiber-Reinforced Epoxy Polymer Winding Pipes.
Polymers (Basel)
December 2024
School of Civil Engineering, Harbin Institute of Technology (HIT), 73 Huanghe Road, Nangang District, Harbin 150090, China.
Carbon-glass hybrid fiber-reinforced epoxy polymer (C-GFRP) winding pipes integrated with the advantages of light weight, high strength, corrosion resistance, and cost-effectiveness offer immense potential to mitigate corrosion issues in oil, gas, and water transportation pipelines. In this study, C-GFRP winding pipes underwent accelerated aging tests through immersion in distilled water at temperatures of 25 °C, 40 °C, and 60 °C for 146 days. Water absorption tests were conducted to investigate the water absorption behavior of only CFRP- or GFRP-side absorbed water.
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