AI Article Synopsis
- ClC-2 is a chloride channel that is widely found in the body and has unclear roles in brain function.
- A study published in Neuron by Jeworutzki et al. identifies a protein called GlialCAM as an important helper for the ClC-2 channel.
- GlialCAM is associated with leukodystrophy, a type of brain disorder, suggesting a potential connection between ClC-2 function and neurological diseases.
Article Abstract
ClC-2 is a broadly distributed chloride channel with an enigmatic neurophysiological function. In this issue of Neuron, Jeworutzki et al. (2012) use a biochemical approach to identify GlialCAM, a protein with a defined link to leukodystrophy, as a ClC-2 auxiliary subunit.
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Megalencephalic leukoencephalopathy with subcortical cysts: A personal biochemical retrospective.
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Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a rare type of leukodystrophy characterized by dysfunction of the role of glial cells in controlling brain fluid and ion homeostasis. Patients affected by MLC present macrocephaly, cysts and white matter vacuolation, which lead to motor and cognitive impairments. To date, there is no treatment for MLC, only supportive care.
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