AI Article Synopsis
- Portal vein thrombosis (PVT) can occur in patients with inflammatory bowel disease (IBD), as shown in a study of 8 cases which included partial PVT and portal cavernoma.
- Four patients showed signs of hypercoagulability, with various risk factors like lupus anti-coagulant and elevated homocysteine levels.
- After receiving anticoagulant therapy, none of the patients experienced further thrombotic events over a median follow-up of 5 years, indicating a generally positive clinical outcome.
Article Abstract
Background And Methods: Portal vein thrombosis (PVT) has been reported as a complication of IBD in some case reports. We describe the presentation, diagnostic approaches, underlying risks factors and clinical outcome of 8 IBD patients with PVT. CASE-SERIES: The patients presented with partial PVT (4 patients) or portal cavernoma. Five patients had undergone surgery. In 2 patients portal biliopathy was diagnosed after detection of PVT. In 4 patients, the diagnosis of PVT was made while IBD was in remission. Five patients showed at least one risk factor for hypercoagulability: lupus anti-coagulant (one patient), increased von Willebrand factor (2 patients) or homocysteine levels (4 patients). Four patients received anticoagulant therapy for 6 months. None experienced other thrombotic events during a median of 5 years (range 2-8 years).
Conclusion: PVT is a potential complication of IBD, usually associated with acquired or inherited risks factors for hypercoagulability and with a benign outcome.
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| http://dx.doi.org/10.1016/j.crohns.2011.10.003 | DOI Listing |
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