The Doppler ultrasound technique was used to study blood flow characteristics for the evaluation of the efficacy of the treatment of painful neurological syndromes with the help of a DiaDENS apparatus allowing for dynamic changes of electrostimulation parameters. A significant improvement of the extracranial cerebral blood flow was achieved as early as the mid-course of 10 treatment sessions when the most pronounced stabilization of the clinical characteristics was apparent. Marked heterogeneity of responses of extracranial vessels to the therapeutic effect of dynamic electrostimulation (DENS) was documented, possibly due to the redistribution of the blood flow in certain vascular areas during the treatment. DENS applied to the lumbar region was shown to induce positive dynamics of the initially impaired blood flow in the tibial artery. It is concluded that positive hemodynamic changes in the cerebral blood flow constitute an important component of the anesthetic and general sanogenetic actions of DENS.
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Genomics
January 2025
Anhui University of Science and Technology, Huainan 232000, China. Electronic address:
Background: Systemic Lupus Erythematosus (SLE) is a typical autoimmune disease characterized by a complex pathogenesis and a strong genetic predisposition. The study of inflammatory response in SLE monocytes is not very clear, and exploring the inflammatory factors of monocytes is beneficial to discover new diagnostic targets.
Results: Using scRNA-seq technology, we obtained the quantitative changes in circulating immune cells and various cellular immune metabolic profiles between SLE patients and healthy volunteers.
Matrix Biol
January 2025
Department of Surgery, Emory University, Atlanta, GA, USA; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA; Research Services, Atlanta VA Medical Center, Decatur, GA, USA. Electronic address:
Arterial endothelial cells (ECs) reside in a complex biomechanical environment. ECs sense and respond to wall shear stress. Low and oscillatory wall shear stress is characteristic of disturbed flow and commonly found at arterial bifurcations and around atherosclerotic plaques.
View Article and Find Full Text PDFPhytomedicine
January 2025
Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China,; Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou 325027, China, ; The Second Clinical Medical College of Wenzhou Medical University, Wenzhou 325027, China. Electronic address:
Background: The significant distal necrosis of the random-pattern skin flaps greatly restricts their clinical applications in flap transplantation. Previous studies have demonstrated the potential of danshensu (DSS) to alleviate ischemic tissue injury. However, no research to date has confirmed whether DSS can improve the survival of ischemic flaps.
View Article and Find Full Text PDFAm J Gastroenterol
January 2025
Center for Biomarker Discovery and Validation, National Infrastructures for Translational Medicine (PUMCH), Institute of Clinical Medicine, Peking Union Medical College Hospital, Beijing, China.
Objectives: Hypertriglyceridemia-associated acute pancreatitis (HTG-AP) is one of the most common etiologies of acute pancreatitis (AP) worldwide. Compared to other etiologies, patients with HTG-AP may develop more severe AP, but previous studies yielded controversial conclusion due to the lack of adequate adjustment for the confounders. Therefore, this study aimed to examine the possibility and risk factors of developing severe AP in HTG-AP.
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