A precise, accurate and well documented method for the sizing and counting of microbubbles is essential for all aspects of quantitative microbubble-enhanced ultrasound imaging. The efficacy of (a) electro-impedance volumetric zone sensing (ES) also called a Coulter counter/multisizer; (b) optical microscopy (OM); and (c) laser diffraction (LD), for the sizing and counting of microbubbles was assessed. Microspheres with certified mean diameter and number concentration were used to assess sizing and counting reproducibility (precision) and reliability (accuracy) of ES, OM and LD. SonoVue™ was repeatedly (n = 3) sized and counted to validate ES, OM and LD sizing and counting efficacy. Statistical analyses of intra-method variability for the SonoVue™ mean diameter showed that the best microbubble sizing reproducibility was obtained using OM with a mean diameter sizing variability of 1.1%, compared with a variability of 4.3% for ES and 7.1% for LD. The best microbubble counting reproducibility was obtained using ES with a number concentration variability of 8.3%, compared with a variability of 22.4% for OM and 32% for LD. This study showed that no method is fully suited to both sizing and counting of microbubbles.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657178 | PMC |
| http://dx.doi.org/10.1016/j.ultrasmedbio.2012.01.012 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The potential of photon-counting CT for the improved precision of lung nodule radiomics.
Phys Med Biol
January 2025
Department of Radiology, Duke University, Suite 302 Hock Plaza, 2424 Erwin Rd, Durham, North Carolina, 27708-0187, UNITED STATES.
Lung nodule appearance may provide prognostic information, as the presence of spiculation increases the suspicion of a nodule being cancerous. Spiculations can be quantified using morphological radiomics features extracted from CT images. Radiomics features can be affected by the acquisition parameters and scanner technologies; thus, it is essential to identify imaging conditions that provide reliable measurements, particularly for emerging technologies like photon-counting CT.
View Article and Find Full Text PDFThe effect of replacing prolonged sitting with intermittent standing during a simulated workday on the subsequent night's sleep.
Sleep Biol Rhythms
January 2025
Department of Epidemiology and Biostatistics, University of West Virginia, Morgantown, WV USA.
A bout of leisure-time physical activity improves sleep on the subsequent night. However, whether breaking up sedentary time during the workday improves sleep is unknown. The purpose of this study was to examine whether breaking up prolonged sitting by standing during the workday leads to better sleep the following night.
View Article and Find Full Text PDFA New Anti-Interfering Platelet Counting Technology Utilizing Conventional Impedance and White Blood Cell Differential Channel.
Int J Lab Hematol
January 2025
Department of Laboratory Medicine, The Third Xiangya Hospital, Central South University, Changsha, People's Republic of China.
Introduction: Accurate platelet (PLT) counting is crucial for disease diagnosis and treatment, especially under the condition of thrombocytopenia and platelet transfusion. A few PLT counting approaches have been established including impedance and fluorescent methods. The impedance PLT counting (PLT-I) approach could be interfered by small non-PLT particles in the blood, such as RBC/WBC fragments, microcytes, bacteria, and cryoglobulins.
View Article and Find Full Text PDFEmission Reduction Characteristics of Heavy-Fuel Aircraft Piston Engine Fueled with 100% HEFA Sustainable Aviation Fuel.
Environ Pollut
January 2025
School of Energy and Power Engineering, Beihang University, Beijing, 100083, China. Electronic address:
With the projected expansion of the general aviation sector and recent breakthroughs in sustainable aviation fuels (SAF), accurately measuring emissions from novel aircraft engines powered by SAF is paramount for evaluating the role of aviation industry in emission reduction trends and environmental consequences. Current SAF research primarily centers on low blend ratios, neglecting data on 100% SAF. This study bridges this gap by experimentally determining emissions indices for gaseous pollutants (CO, CO, HC, NOx), total particulate matter (PM) counts and sizes, and non-volatile particulate matter (nvPM) number and mass concentrations from a heavy-fuel aircraft piston engines (HF-APE) using hydroprocessed esters and fatty acids-derived SAF (HEFA-SAF), adhering to airworthiness-standard sampling and measurement protocols.
View Article and Find Full Text PDFPurpose: With the widespread introduction of dual energy computed tomography (DECT), applications utilizing the spectral information to perform material decomposition became available. Among these, a popular application is to decompose contrast-enhanced CT images into virtual non-contrast (VNC) or virtual non-iodine images and into iodine maps. In 2021, photon-counting CT (PCCT) was introduced, which is another spectral CT modality.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!