Aim: The cell cycle regulator cyclin D1 (CCND1) is a critical regulator of the G1/S phase transition and plays an important part in several tumor types. This study aimed at investigating the association of CCND1 with and examining the interaction among CCND1 genotype and individual smoking habit in nasopharyngeal carcinoma susceptibility.
Patients And Methods: A total of 352 native Taiwanese consisting of 176 cases and 176 controls were enrolled in this hospital-based study, and CCND1 A870G (rs9344) and C1722G (rs678653) genotyping were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and partially verified by direct sequencing.
Results: The results showed that there were significant differences between nasopharyngeal carcinoma and control groups in the distribution of the genotypic (p=0.0222) and allelic (p=0.0322) frequencies in the CCND1 A870G genotype. Individuals who carried at least one G allele (GG or AG) had a 0.71-fold lower risk of developing nasopharyngeal carcinoma compared to those who had the AA genotype (95% confidence interval=0.53-0.96). In addition, there is an obvious joint effect of CCND1 A870G genotype with smoking habit on nasopharyngeal carcinoma susceptibility.
Conclusion: These findings support the conclusion that the cell cycle regulation may play a role in nasopharyngeal carcinoma development and that CCND1 A870G polymorphism maybe a useful biomarker for nasopharyngeal carcinoma progression.
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Front Nutr
January 2025
Hunan Provincial Key Laboratory of the Fundamental and Clinical Research, Changsha Medical University, Changsha, China.
Objectives: Patients with nasopharyngeal carcinoma (NPC) are prone to malnutrition, which leads to deterioration of health. This study is to clarify the effect of Artificial intelligence (AI)-assisted home enteral nutrition (HEN) management mode on the health status of patients with stage III to stage IV NPC after 3 years of treatment, and to provide a new strategy for improving the quality of life of patients.
Methods: Patients with stage III ~ IV NPC were determined whether to accept AI-assisted HEN management according to voluntary principle.
Quant Imaging Med Surg
January 2025
Department of Radiology, Medical Imaging Institute of Tianjin, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China.
Background: Although the spatial heterogeneity of glioblastoma (GBM) can be clearly mapped by the habitats generated by magnetic resonance imaging (MRI), the means to accurately predicting the spatial location of local recurrence (SLLR) remains a significant challenge. The aim of this study was to identify the different degrees enhancement of GBM, including the nontumor component and tumor component, and determine their relationship with SLLR.
Methods: A retrospective analysis was performed from three tertiary medical centers, totaling 728 patients with 109 radiation-induced temporal lobe necrosis (TLN) of nasopharyngeal carcinoma (NPC) and 619 with GBM.
Nucl Med Commun
January 2025
Department of Nuclear Medicine, Fudan University Shanghai Cancer Center.
Objective: The objective of this study is to evaluate and compare the clinical utility of 18F-fluoro-2-deoxy-d-glucose PET and computed tomography (18F-FDG PET/CT) in detecting recurrence and metastasis in patients with nasopharyngeal carcinoma (NPC) who exhibit elevated levels of Epstein-Barr virus (EBV) DNA following treatment.
Methods: A total of 103 patients with NPC were studied retrospectively. All patients were in remission following initial treatment.
BMC Cancer
January 2025
School of Medicine, IMU University (Formerly Known as the International Medical University), Kuala Lumpur, Malaysia.
Background: Nasopharyngeal carcinoma (NPC) is one of the most common head and neck cancers worldwide. The majority of the new cases were from Asia and are the leading cause of cancer in China. The main treatment is surgery and radiotherapy with chemotherapy for advanced cases.
View Article and Find Full Text PDFNat Commun
January 2025
CAS Engineering Laboratory for Nanozyme, Key Laboratory of Biomacromolecules (CAS), CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Nasopharyngeal carcinoma (NPC), a malignancy highly prevalent in East and Southeast Asia, is primarily treated with radiotherapy (RT). However, hypoxia-induced radioresistance presents a significant challenge. Nanozymes, nanomaterials with catalase-like activity, have emerged as a promising strategy for radiosensitization by converting elevated hydrogen peroxide in the tumor microenvironment into oxygen.
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