Collagen type VI is a subepithelial extracellular matrix component in airways and an adhesive substrate for oral pathogens [Bober et al.: J Innate Immun 2010;2:160-166]. Here, we report that collagen VI displays a dose-dependent antimicrobial activity against group A, C, and G streptococci by membrane disruption in physiological conditions. The data disclose previously unrecognized aspects of the extracellular matrix in innate host defense.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6741453 | PMC |
| http://dx.doi.org/10.1159/000335239 | DOI Listing |
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