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Recurrent and Metastatic Head and Neck Cancer: Mechanisms of Treatment Failure, Treatment Paradigms, and New Horizons.
Cancers (Basel)
January 2025
Department of Otolaryngology-Head and Neck Surgery, Louisiana State University Health Sciences Center, New Orleans, LA 71103, USA.
Head and neck cancer is a deadly disease with over 500,000 cases annually worldwide. Metastatic head and neck cancer accounts for a large proportion of the mortality associated with this disease. Many advances have been made in our understanding of the mechanisms of metastasis.
View Article and Find Full Text PDFStretchView - A Multi-Axial Cell-Stretching Device for Long-Term Automated Videomicroscopy of Living Cells.
Adv Sci (Weinh)
January 2025
Institute of Microtechnology (IMT), Technische Universität Braunschweig, Alte Salzdahlumer Str. 203, 38124, Braunschweig, Germany.
Incorporating mechanical stretching of cells in tissue culture is crucial for mimicking (patho)-physiological conditions and understanding the mechanobiological responses of cells, which can have significant implications in areas like tissue engineering and regenerative medicine. Despite the growing interest, most available cell-stretching devices are not compatible with automated live-cell imaging, indispensable for characterizing alterations in the dynamics of various important cellular processes. In this work, StretchView is presented, a multi-axial cell-stretching platform compatible with automated, time-resolved live-cell imaging.
View Article and Find Full Text PDFUS and Canadian cat caregiver's ratings of cat-cat interactions: A video-based survey.
Anim Welf
December 2024
Department of Animal Science, University of California, Davis, CA, USA.
US and Canadian caregivers (n = 6,529) of two domestic cats () were recruited to participate in an online cross-sectional questionnaire to assess: (1) knowledge of inter-cat behaviour; (2) the frequency of positive and negative cat-cat interactions in the home; and (3) factors associated with positive and negative cat-cat interactions in the home. The questionnaire included ten videos (five negatively valenced, five positively valenced), in which participants scored: the overall cat-cat interaction; cat 1's experience; and cat 2's experience, using a Likert scale. Participants were also asked to report how often they see each interaction in their own two cats.
View Article and Find Full Text PDFLife beyond a jar: Effects of tank size and furnishings on the behaviour and welfare of Siamese fighting fish ().
Anim Welf
December 2024
Macquarie University, School of Natural Sciences, Australia.
Globally, Siamese fighting fish () continue to be sold and kept in small, barren jars or tanks, with little concern for their welfare. This study aimed to examine the impact of housing size and furnishings (i.e.
View Article and Find Full Text PDFThe and of Vincent van Gogh: neuropeptides of bondedness and loss.
Front Psychol
December 2024
Department of Neurobiology and Biophysics, University of Washington, Seattle, WA, United States.
We introduce two Korean-named yet transcultural feelings, and , to fill gaps in neuroscientific understanding of mammalian bondedness, loss, and aggression. is a visceral sense of connectedness to a person, place, or thing that may arise after proximity, yet does not require intimacy. The brain opioid theory of social attachment (BOTSA) supports the idea that involves increased activity of enkephalins and beta-endorphins.
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