AI Article Synopsis
- Pectus excavatum and pectus carinatum are the most common types of chest wall deformities, but their causes are not well understood, and research findings vary.
- The article reviews the historical context of these conditions, analyzing early clinical descriptions and various theories on their development.
- It emphasizes the significance of embryonic rib and sternum development disruptions, discusses therapeutic methods based on these insights, and suggests innovative biomaterial approaches for potential tissue engineering treatments.
Article Abstract
Pectus excavatum and pectus carinatum represent the most frequent chest wall deformations. However, the pathogenesis is still poorly understood and research results remain inconsistent. To focus on the recent state of knowledge, we summarize and critically discuss the pathological concepts based on the history of these entities, beginning with the first description in the sixteenth century. Based on the early clinical descriptions, we review and discuss the different pathogenetic hypotheses. To open new perspectives for the potential pathomechanisms, the embryonic and foetal development of the ribs and the sternum is highlighted following the understanding that the origin of these deformities is given by the disruption in the maturation of the parasternal region. In the second, different therapeutical techniques are highlighted and based on the pathogenetic hypotheses and the embryological knowledge potential new biomaterial-based perspectives with interesting insights for tissue engineering-based treatment options are presented.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352718 | PMC |
| http://dx.doi.org/10.1093/icvts/ivs045 | DOI Listing |
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