[Application of bacterial thermo-and phagelysates for suppression of malignant tumor growth in experimental studies: 1. Anticancer efficacy of thermo- and phagelysates of E.coli].

Immunotherapy is considered as one of the promising treatment strategies for patients with malignant tumors. In the presented work antitumor effects of E.coli thermo- and phagelysates on Ehrlich carcinoma growth in mice have been studied. The treatment efficacy was evaluated by estimation of dynamic changes in volume of cancer tissue and by the percentage of cancer growth inhibition. Semi-empirical mathematical model, describing cancer volume variations in relation to time, passed after Ehrlich carcinoma inoculation was elaborated. It was shown that at the early stage of cancer growth both tested bacterial preparations significantly inhibit cancer growth. Antitumor treatment effects were better expressed in animal studies using bacterial phagelysates in comparison to that of thermolysates. After cessation of administration of bacterial preparations a prolonged antitumor activity in animals treated with E. coli phagelysates was demonstrated.