Today hyperfractionated radiotherapy in combination with cisplatin and 5-FU is the most effective treatment modality of patients with nasopharyngeal carcinoma. However late complications of this method are investigated poorly what was the aim of this research. Analyzing treatment results of 118 patients who achieved complete tumor regression we revealed that radiation damages more often and severe at patients who received more aggressive treatment - accelerated hyperfractionated radiotherapy with and without concurrent cytotoxic drugs. But application of complex prophylaxis and treatment measures by radiation oncologists in cooperation with other specialist (stomatologists, dermatologists, endocrinologists etc.) allow to control toxicity and finalize planned treatment schedule.
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