Influence of sealant fibrin on the wound healing of the pigs vocal folds.

Unlabelled: Fibrin sealants or fibrin glue are products made from human plasma proteins, which mimic the final pathway of the coagulation cascade. Its application to stimulate the healing process has been a topic of debate in the literature. The use of fibrin sealants in phonosurgery has been empirical; there have been no studies that investigate the action of fibrin sealant in Reinke's space.

Aim: To evaluate the effect of fibrin glue in healing of the vocal folds of pigs after surgical manipulation.

Materials And Methods: This was a prospective and experimental study. Six animals had both vocal folds incised. Sealant was applied in one of them; the other served as a control. After three months, the animals were sacrificed and a collagen count was carried out.

Results: The side on which glue was applied had an average of 27.8% against 20.4% of the side without glue.

Conclusion: The collagen concentration in the samples where the fibrin sealant was applied was significantly higher compared to samples without glue. Thus, the presence of a fibrin sealant stimulates fibrogenesis in this tissue.