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Topical Tacrolimus in Vitiligo: Consensus Paper from the Pigmentary Disorders Society.
Clin Cosmet Investig Dermatol
December 2024
Consultant Dermatologist, Indore, Madhya Pradesh, India.
Background: Tacrolimus, a topical calcineurin inhibitor (TCI) with immunomodulatory effects, is considered a viable treatment option for vitiligo. A consensus building exercise was undertaken to determine the role and clinical utility of topical tacrolimus in the management of vitiligo using input from experts in the field of dermatology.
Methods: Seventeen experts collaborated to create consensus statements using a modified Delphi methodology.
High-Sensitivity, High-Resolution Miniaturized Spectrometers for Ultraviolet to Near-Infrared Using Guided-Mode Resonance Filters.
Molecules
November 2024
School of Electronic and Optical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China.
Miniaturized spectrometers have significantly advanced real-time analytical capabilities in fields such as environmental monitoring, healthcare diagnostics, and industrial quality control by enabling precise on-site spectral analysis. However, achieving high sensitivity and spectral resolution within compact devices remains a significant challenge, particularly when detecting low-concentration analytes or subtle spectral variations critical for chemical and molecular analysis. This study introduces an innovative approach employing guided-mode resonance filters (GMRFs) to address these limitations.
View Article and Find Full Text PDFZosteriform mycosis fungoides: case report of progression to tumor stage and review of the literature.
Dermatol Online J
August 2024
Division of Dermatology, Tokushima Red Cross Hospital, Tokushima, Japan.
Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma, although it has many clinicopathological variants. Zosteriform MF is an extremely rare variant characterized by dermatomal distribution. To date, only six patients with zosteriform MF have been reported.
View Article and Find Full Text PDFPhototherapy as an alternative in the treatment of chronic spontaneous urticaria.
Front Allergy
November 2024
Allergy Unit, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
Chronic spontaneous urticaria (CSU) is defined as the occurrence of hives, angioedema, or both, lasting for more than 6 weeks. The treatment is based on the use of antihistamines, omalizumab, and/or cyclosporine following a stepwise algorithm recommended by international guidelines with a high level of evidence. Nevertheless, management can be challenging as some patients do not respond to the suggested drugs or have difficulties accessing them for various reasons.
View Article and Find Full Text PDFLow-Dose Melittin Enhanced Pigment Production Through the Upregulation of Tyrosinase Activity and Dendricity in Melanocytes by Limiting Oxidative Stress: A Therapeutic Implication for Vitiligo.
Antioxidants (Basel)
November 2024
Department of Cardiac Biochemistry, All India Institute of Medical Sciences (AIIMS), New Delhi 110029, India.
Article Synopsis
- - Melittin, a key component of bee venom, has various biological effects including anti-inflammatory and anti-tumor properties, but its impact on melanin production in human melanocytes was previously unclear.
- - The study investigated how different doses of melittin affect melanin production, cell viability, and related gene expression in cultured human melanocytes, particularly when combined with narrow-band ultraviolet B (NB-UVB) treatment.
- - Results showed that low doses of melittin, alone or with NB-UVB, increased melanin content and tyrosinase activity in melanocytes, suggesting its potential use in treating conditions like vitiligo by enhancing melanin synthesis while reducing oxidative stress.
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