Background: The present paper is a first evaluation of the use of "CEAwatch", a clinical support software system for surgeons for the follow-up of colorectal cancer (CRC) patients. This system gathers Carcino-Embryonic Antigen (CEA) values and automatically returns a recommendation based on the latest values.

Methods: Consecutive patients receiving follow-up care for CRC fulfilling our in- and exclusion criteria were identified to participate in this study. From August 2008, when the software was introduced, patients were asked to undergo the software-supported follow-up. Safety of the follow-up, experiences of working with the software, and technical issues were analyzed.

Results: 245 patients were identified. The software-supported group contained 184 patients; the control group contained 61 patients. The software was safe in finding the same amount of recurrent disease with fewer outpatient visits, and revealed few technical problems. Clinicians experienced a decrease in follow-up workload of up to 50% with high adherence to the follow-up scheme.

Conclusion: CEAwatch is an efficient software tool helping clinicians working with large numbers of follow-up patients. The number of outpatient visits can safely be reduced, thus significantly decreasing workload for clinicians.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3330015PMC
http://dx.doi.org/10.1186/1472-6947-12-14DOI Listing

Publication Analysis

Top Keywords

carcino-embryonic antigen
8
follow-up
8
patients
8
follow-up patients
8
colorectal cancer
8
group contained
8
outpatient visits
8
software
6
evaluation decision-support
4
decision-support software
4

Similar Publications

Background/aim: The study examines whether DNA level mutations in the carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) gene Pro-Glu-Leu-Pro-Lys (PELPK) motif differ between patients with appendiceal or colorectal adenocarcinoma. Significant differences between these two groups in correlation with development of metachronous liver metastases could help in the development of targeted therapies and preventative treatment approaches.

Patients And Methods: This retrospective comparative trial analysed 18 patients, 9 with appendiceal adenocarcinoma and 9 with colorectal adenocarcinoma.

View Article and Find Full Text PDF
Article Synopsis
  • Serum carcinoembryonic antigen (CEA) is indicated as a valuable prognostic biomarker for recurrence and survival in patients with early non-small cell lung cancer (NSCLC) after curative surgery.
  • The study involved 18 patients with early-stage NSCLC, measuring their serum CEA levels before and after surgical resection over a follow-up period, revealing that 39% had elevated pre-operative CEA levels.
  • Results showed that patients with a baseline CEA level above 5.0 ng/ml had significantly poorer disease-free survival compared to those with lower levels, underlining the potential of CEA to identify patients at risk for worse outcomes.
View Article and Find Full Text PDF

Aims: Breast cancer is the second leading cause of death worldwide. Conventional chemotherapeutic therapies lack the specific targeting effect toward the cancerous cells resulting in extensive side effects. Our current study endeavors to prepare novel bioinspired folic acid-functionalized caffeic acid (CA)-loaded casein nanoparticles (CS NPs) for curbing breast cancer.

View Article and Find Full Text PDF

Background: Preoperative accurate visceral pleural infiltration (VPI) diagnosis for T1-size non-small cell lung cancer (NSCLC) is significant for clinical decision-making. The study aimed to explore the diagnostic efficacy of computed tomography (CT) imaging features and serum biomarkers in diagnosing VPI in newly discovered subpleural NSCLC ≤3 cm.

Methods: There were 447 patients with NSCLC ≤3 cm retrospectively enrolled and assigned to the VPI group (n=81) and the non-VPI group (n=366) based on elastic fiber staining results.

View Article and Find Full Text PDF
Article Synopsis
  • Early-stage gastric cancer often goes undetected due to a lack of specific symptoms, resulting in late diagnoses and advanced disease, highlighting the need for new biomarkers for early detection and treatment matching.
  • The study investigated the prognostic significance of ENPP2/Autotaxin (ATX) and lysophosphatidic acid (LPA) in Gastro-Esophageal Adenocarcinoma (GEA), finding that higher levels of these substances could indicate worse patient outcomes.
  • Results showed that while ENPP2 mutations are infrequent, they are linked to lower overall survival, and surgical removal of tumors significantly reduced serum ATX and LPA levels, suggesting potential for targeted therapies based on these biomarkers in future clinical trials.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!