AI Article Synopsis
- This study examines how the concentration of PEG 6000 as a melt binder and the ratio of HPMC K4M to PVP affect the release of Zolpidem tartrate in controlled-release tablets using a systematic factorial design.
- The independent variables were the ratio of HPMC to PVP and the concentration of the melt binder, while drug release at different time points and other release parameters were the dependent variables.
- Results indicated that the concentration of the melt binder significantly influenced drug release metrics, with a 25% concentration being optimal, whereas the ratio of HPMC to PVP did not significantly affect the outcomes.
Article Abstract
The present investigation describes the influence of the concentration of PEG 6000 as a melt binder and ratio of HPMC K4M : PVP on Zolpidem tartrate controlled-release tablet formulations using 3(2) full factorial design. The ratio of HPMC K4M and PVP K30 (X(1)) and the concentration of melt binder (X(2)) were selected as independent variables, and drug release at 1 hr (Q(1)), 4 hr (Q(4)), 8 hr (Q(8)), diffusion coefficient (n), and release rate constant (K) were selected as a dependent variable. Tablets were prepared by melt granulation technique and evaluated for various evaluation parameters. It was observed that concentration of melt binder had significant effect on Q(1), Q(4), n, and K Binder concentration 25% w/w was found optimum. Optimized formulation (F(7)) showed good similarity with theoretical profile of drug. The X(2) variable had a significant effect on dependent variables, and the X(1) variable had no significant effect on dependent variables.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263716 | PMC |
| http://dx.doi.org/10.5402/2011/208394 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!