Human metapneumovirus and respiratory syncytial virus cause lower respiratory tract infections. The virus fusion (F) glycoprotein promotes membrane fusion by refolding from a metastable pre-fusion to a stable post-fusion conformation. F is also a major target of the neutralizing antibody response. Here we show that a potently neutralizing anti-human metapneumovirus antibody (DS7) binds a structurally invariant domain of F, revealing a new epitope that could be targeted in vaccine development.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546531 | PMC |
| http://dx.doi.org/10.1038/nsmb.2250 | DOI Listing |
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