AI Article Synopsis
- MIC-1/GDF15 is a protein linked to various biological processes and has been identified as a potential biomarker for cardiovascular disease and atherosclerosis treatment outcomes.
- After studying transgenic mice with increased MIC-1 expression, researchers found that these mice had smaller atherosclerotic lesions compared to controls on a high-fat diet.
- Despite the size reduction in lesions, there were no significant changes in lesion composition or inflammatory markers, indicating that while MIC-1 seems protective, its specific mechanisms remain unclear and need further research.
Article Abstract
Aim: MIC-1/GDF15 is a member of the TGF-b superfamily, which is thought to have pleiotropic roles in stress responses, inflammation, tissue injury and repair, energy homeostasis, and malignancy. MIC-1/GDF15 was recently identified as a new biomarker for the development of cardiovascular events and the outcome of atherosclerotic disease therapy. The aim of our study was to determine if MIC-1 also directly exerts pro- or antiatherogenic properties during the development of atherosclerosis.
Methods And Results: We investigated the effect of transgenic overexpression of MIC-1 in macrophages in the ApoE(-/-) mouse model of atherosclerosis. After 6 months of high-fat diet, MIC-1/GDF15 transgenic ApoE(-/-) mice had smaller atherosclerotic lesions; however, no differences in lesion composition, pro- or anti-inflammatory cytokine production, or serum levels of lipids or cytokines were detected.
Conclusions: Our results suggest that MIC-1 has an overall protective effect on the disease process, but further studies will be required to define its mechanism of action.
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| http://dx.doi.org/10.1016/j.carpath.2012.02.003 | DOI Listing |
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