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Reconsidering remission in recurrent late-life depression: clinical presentation and phenotypic predictors of relapse following successful antidepressant treatment.
Psychol Med
January 2025
Department of Psychiatry, University of Illinois-Chicago, Chicago, IL, USA.
Background: Late-life depression (LLD) is characterized by repeated recurrent depressive episodes even with maintenance treatment. It is unclear what clinical and cognitive phenotypic characteristics present during remission predict future recurrence.
Methods: Participants (135 with remitted LLD and 69 comparison subjects across three institutions) completed baseline phenotyping, including psychiatric, medical, and social history, psychiatric symptom and personality trait assessment, and neuropsychological testing.
Optimizing Pyrazinamide Use: A Low-Hanging Fruit in Improving Outcomes with Tuberculous Meningitis? Narrative Review.
Infect Dis Ther
January 2025
Christian Medical College, Vellore, Tamil Nadu, India.
Tuberculous meningitis (TBM) disables more than a third of its sufferers. Recent research has focused on optimizing the antitubercular regimen, mainly by increasing the dosage of rifampicin. However, pyrazinamide, with higher penetration into the central nervous system, is generally overlooked.
View Article and Find Full Text PDFCancer Rehabilitation: Reconsidering the Inpatient Rehabilitation Facility Classification Criteria for Payment Under the Prospective Payment System.
J Allied Health
December 2024
Dep. of Rehabilitation Sciences, Indiana University South Bend, 125 E. Franklin Street, Elkhart, IN 46516, USA. Tel 574-520-4033.
Article Synopsis
- - Inpatient rehabilitation facilities (IRFs) play a vital role in helping individuals recover after acute care, but their admission criteria have not changed since the 1970s, limiting access for cancer patients even with evidence of their need for rehab.
- - The Biden administration's relaunch of the Cancer Moonshot in 2022 focuses on improving cancer patients' quality of life and highlights the need to reassess IRF admission and reimbursement practices.
- - By evaluating the current policies and considering alternative solutions, like modifying the eligibility criteria for IRF care, access for cancer patients could be significantly improved, potentially leading to better outcomes and long-term cost savings despite initial higher expenses.
What is the Optimal Treatment Protocol for Traumatic Popliteal Artery Injury? A Comparative Study between Two Institutions.
J Emerg Trauma Shock
September 2024
Department of Orthopaedic Surgery, Kobe City Medical Center General Hospital, Kobe, Japan.
Article Synopsis
- Popliteal artery injury, although rare, can lead to severe complications like limb ischemia and potential amputation, prompting the need for effective treatment strategies.
- The study analyzed patient records from two hospitals between 2011 and 2022, comparing treatment outcomes, particularly focusing on the time to reperfusion and types of interventions used for popliteal artery injuries.
- Results indicated that the hospital using temporary vascular shunting had significantly shorter reperfusion times and better clinical outcomes, suggesting the importance of prompt diagnosis and systematic treatment protocols.
The World Turned Upside Down: Wonder, Disgust, and the Alienation Effect.
Perspect Biol Med
November 2024
History shows alarming shifts in the way that people with intellectual disabilities have been regarded. Locke doubted whether they could be counted among the human, while Rousseau hailed them as unspoiled children who could help us be better; the eugenicists despised them as perpetuating "feeble-mindedness," while the religious praised them as holy innocents. Throughout, however, they have been seen metaphorically, as symbolic figures who incite hatred or inspire wonder, but rarely as real people.
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