The structure of the title compound, [U(C(14)H(9)N(3)O(2))O(2)(CH(3)OH)(2)]·CH(3)OH, is the first to be reported for an actinide complex including triazole ligands. The U(VI) atom exhibits a pentagonal-bipyramidal NO(6) coordination environment, involving two axial oxide ligands [U=O = 1.766 (3) and 1.789 (3) Å], four equatorial O atoms [U-O = 2.269 (3)-2.448 (3) Å] from the ligand and the two coordinated methanol molecules, and one equatorial N atom [U-N = 2.513 (4) Å] from the ligand. In the crystal structure, the complex molecules are linked via intermolecular N-H...O and O-H...O hydrogen bonds to form a two-dimensional structure.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1107/S0108270112003034 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The question of strains in AA amyloidosis.
Sci Rep
January 2025
Department of Immunology, Genetics and Pathology, Uppsala University, Rudbeck Laboratory, C11, 75185, Uppsala, Sweden.
The existence of transmissible amyloid fibril strains has long intrigued the scientific community. The strain theory originates from prion disorders, but here, we provide evidence of strains in systemic amyloidosis. Human AA amyloidosis manifests as two distinct clinical phenotypes called common AA and vascular AA.
View Article and Find Full Text PDFExploring the Structure-Activity Relationships of Albumin-Targeted Picoplatin-Based Platinum(IV) Prodrugs.
Inorg Chem
January 2025
Faculty of Chemistry, Institute of Inorganic Chemistry, University of Vienna, Waehringer Str. 42, 1090 Vienna, Austria.
Platinum(II) complexes prevail as first-line treatment for many cancers but are associated with serious side effects and resistance development. Picoplatin emerged as a promising alternative to circumvent GSH-induced tumor resistance by introducing a bulky 2-picoline ligand. Although clinical studies were encouraging, picoplatin did not receive approval.
View Article and Find Full Text PDFResveratrol-Based Carbamates as Selective Butyrylcholinesterase Inhibitors: Design, Synthesis, Computational Study and Biometal Complexation Capability.
Molecules
January 2025
Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Trg Marka Marulića 19, HR-10 000 Zagreb, Croatia.
Considering our previous experience in the design of new cholinesterase inhibitors, especially resveratrol analogs, in this research, the basic stilbene skeleton was used as a structural unit for new carbamates designed as potentially highly selective butyrylcholinesterase (BChE) inhibitors with excellent absorption, distribution, metabolism, excretion and toxicity ADMET properties. The inhibitory activity of newly prepared carbamates - was tested toward the enzymes acetylcholinesterase (AChE) and BChE. In the tested group of compounds, the leading inhibitors were and , which achieved excellent selective inhibitory activity for BChE with IC values of 0.
View Article and Find Full Text PDFSonochemical Functionalization of SiO Nanoparticles with Citric Acid and Monoethanolamine and Its Remarkable Effect on Antibacterial Activity.
Materials (Basel)
January 2025
Centro de Investigación y de Estudios Avanzados del IPN-Unidad Mérida, Departamento de Física Aplicada, Mérida 97310, Yucatán, Mexico.
Nanoparticles (NPs) are excellent antibacterial agents due to their ability to interact with microorganisms at the cellular level. However, their antimicrobial capacity can be limited by their tendency to agglomerate. Functionalizing NPs with suitable ligands improves their stability and dispersion in different media and enhances their antibacterial activity.
View Article and Find Full Text PDFDiscovery of PPAR Alpha Lipid Pathway Modulators That Do Not Bind Directly to the Receptor as Potential Anti-Cancer Compounds.
Int J Mol Sci
January 2025
Medical Research Core Facility and Platforms (MRCFP)-Drug Discovery Platform, King Abdullah International Medical Research Center (KAIMRC), King Saud Bin Abdulaziz University for Health Sciences, Ministry of National Guard Health Affairs (MNGHA), Riyadh 11481, Saudi Arabia.
Peroxisome proliferator-activated receptors (PPARs) are considered good drug targets for breast cancer because of their involvement in fatty acid metabolism that induces cell proliferation. In this study, we used the KAIMRC1 breast cancer cell line. We showed that the PPARE-Luciferase reporter gets highly activated without adding any exogenous ligand when PPAR alpha is co-transfected, and the antagonist GW6471 can inhibit the activity.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!