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Mobile Stroke Unit Management in Patients With Acute Ischemic Stroke Eligible for Intravenous Thrombolysis.
JAMA Neurol
December 2024
Memorial Hermann Hospital, Houston, Texas.
Article Synopsis
- Clinical trials indicate that using a mobile stroke unit (MSU) for prehospital management can lead to better outcomes for acute ischemic stroke patients who may need thrombolysis, but real-world data is limited.
- This study aimed to compare the effects of prehospital MSU management versus standard emergency services (EMS) on patient disability levels at the time of hospital discharge.
- The analysis included over 19,000 patients treated across multiple hospitals, revealing that those managed in an MSU had improved functional outcomes compared to those receiving standard EMS care.*
Letter to editor: Comment on "Clinical disease course and survival outcomes following disease recurrence in adenoid cystic carcinoma with and without NOTCH signaling pathway activation".
Oral Oncol
September 2024
Center for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Thandalam, Tamil Nadu, India. Electronic address:
The study by Feeney et al. provides critical insights into the prognostic implications of NOTCH pathway activation in adenoid cystic carcinoma (ACC), particularly after disease recurrence. Utilizing both next-generation sequencing and immunohistochemistry, the research delineates the survival outcomes between NOTCH-activated and non-activated ACC groups, highlighting poorer outcomes in the former.
View Article and Find Full Text PDFNavigating Clinical Variability: Transfer Learning's Impact on Imaging Model Performance.
Radiol Artif Intell
July 2024
From the CISSS Lanaudière-Medical Imaging, 200 Louis-Vadeboncoeur, Saint-Charles-Borromee, QC, Canada J6E 6J2.
Claustrum projections to the anterior cingulate modulate nociceptive and pain-associated behavior.
Curr Biol
May 2024
Department of Pharmacology, University of Alberta, 8613 114 Street NW, Edmonton, AB T6G 2R3, Canada; Neuroscience and Mental Health Institute, University of Alberta, 11315 87 Avenue NW, Edmonton, AB T6G 2E1, Canada; Cancer Research Institute of Northern Alberta, University of Alberta, 11315 87 Avenue NW, Edmonton, AB T6G 2E1, Canada; Department of Anesthesiology and Pain Medicine, University of Alberta, 8440 112 Street NW, Edmonton, AB T6G 2B7, Canada. Electronic address:
The anterior cingulate cortex (ACC) is critical for the perception and unpleasantness of pain. It receives nociceptive information from regions such as the thalamus and amygdala and projects to several cortical and subcortical regions of the pain neuromatrix. ACC hyperexcitability is one of many functional changes associated with chronic pain, and experimental activation of ACC pyramidal cells produces hypersensitivity to innocuous stimuli (i.
View Article and Find Full Text PDFProSE-Pero: Peroxisomal Protein Localization Identification Model Based on Self-Supervised Multi-Task Language Pre-Training Model.
Front Biosci (Landmark Ed)
December 2023
School of Computer Science and Engineering, University of Electronic Science and Technology of China, 611731 Chengdu, Sichuan, China.
Background: Peroxisomes are membrane-bound organelles that contain one or more types of oxidative enzymes. Aberrant localization of peroxisomal proteins can contribute to the development of various diseases. To more accurately identify and locate peroxisomal proteins, we developed the ProSE-Pero model.
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