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Two recent case-control studies, both published in the British Journal of Anaesthesia, have shown that intake of pholcodine-containing cough medicines during the year preceding general anaesthesia significantly increased the risk of anaphylaxis caused by neuromuscular blocking agents. Both a French multicentre study and a single-centre study from Western Australia offer strong support to the pholcodine hypothesis for IgE-sensitisation to neuromuscular blocking agents. The European Medicines Agency, criticised for not taking preventive action at its first assessment of pholcodine in 2011, finally recommended a stop to sales of all pholcodine-containing medicines throughout the EU on December 1, 2022.
View Article and Find Full Text PDFExploiting the power of UPLC in separation and simultaneous determination of pholcodine, guaiacol along with three specified guaiacol impurities.
BMC Chem
April 2023
Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr el Aini Street, Cairo, 11562, Egypt.
Pholcodine and guaiacol are widely used together in pharmaceutical syrups for cough treatment. On the other hand, the Ultra Performance Liquid Chromatographic technique is characterized by having the power of increasing chromatographic efficiency and decreasing run time compared to the traditional High Performance Liquid Chromatographic one. In this work, this power was exploited for the simultaneous determination of pholcodine, guaiacol along with three guaiacol impurities, namely; guaiacol impurity A, guaiacol impurity B, and guaiacol impurity E.
View Article and Find Full Text PDFMedicines and Healthcare products Regulatory Agency. Pholcodine-containing cough and cold medicines: withdrawal from UK market as a precautionary measure. 2023;16:1.
View Article and Find Full Text PDFCough up, time's up: pholcodine and risk of anaphylaxis to general anaesthetics.
Arch Dis Child
July 2023
National Heart & Lung Institute, Imperial College London, London, UK.
[Efficacy of compound pholcodine syrup and compound codeine phosphate oral solution on lung cancer-related cough].
Zhonghua Yi Xue Za Zhi
April 2023
Department of Geriatric Oncology, Chongqing University Cancer Hospital, Chongqing 400030, China.
To assess the clinical efficacy of compound pholcodine syrup and compound codeine phosphate oral solution on lung cancer-related cough. A total of 60 patients diagnosed with middle-advanced stage lung cancer and had lung cancer-related cough in the Department of Geriatric Oncology of Chongqing University Cancer Hospital from January to May 2022 were prospectively enrolled. According to the random number table method, the patients were divided into two groups: observation group and control group.
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