Female rats at the stage of proestrus have been subjected to a stress effect--immobilization for an hour. Oocytes were cytogenetically analyzed and embryonal mortality was determined. It is shown that this stress effect at the end of the fist meiotic division of the oocytes increased the rate of aneuploid gametes and the level of embryonal mortality.
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Stem Cells Transl Med
January 2025
Developmental and Stem Cell Biology Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, ON, Canada M5G 0A4.
Disruption of developmental processes affecting the fetal lung leads to pulmonary hypoplasia. Pulmonary hypoplasia results from several conditions including congenital diaphragmatic hernia (CDH) and oligohydramnios. Both entities have high morbidity and mortality, and no effective therapy that fully restores normal lung development.
View Article and Find Full Text PDFSci Total Environ
January 2025
Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China; CAS Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. Electronic address:
Polychlorinated biphenyls (PCBs), a typical type of persistent organic pollutants (POPs), were previously widely employed as insulating and heat exchange fluids in transformers and capacitors. Despite knowledge of its adverse effects, the precise mechanism underlying PCB77 toxicity remains enigmatic. In this study, we utilized zebrafish as a model organism to explore the toxic effects of various concentrations of PCB77 (10, 200, and 1000 μg/L) and its molecular toxicity mechanisms.
View Article and Find Full Text PDFWarming associated with climate change is driving poleward shifts in the marine habitat of anadromous Pacific salmon ( spp.). Yet the spawning locations for salmon to establish self-sustaining populations and the consequences for the ecosystem if they should do so are unclear.
View Article and Find Full Text PDFChemosphere
January 2025
Ramboll, 3401 Enterprise Place, Suite 340, Beachwood, Ohio 44122, USA. Electronic address:
Egg injection has been used for decades to determine embryonic mortality and developmental effects of chemical exposures in birds. Specific egg injection methods affect how well these studies replicate the process of chemical delivery to the embryo via maternal deposition, yet few data are available to compare exposure-response relationships between egg injection and maternal transfer studies. This information gap creates uncertainty when considering egg injection studies for assessment of potential adverse effects in wild birds.
View Article and Find Full Text PDFInt J Mol Sci
December 2024
Division of Neonatology, Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, MI 48824, USA.
Sepsis is a risk factor associated with increasing neonatal morbidity and mortality, acute lung injury, and chronic lung disease. While stem cell therapy has shown promise in alleviating acute lung injury, its effects are primarily exerted through paracrine mechanisms rather than local engraftment. Accumulating evidence suggests that these paracrine effects are mediated by mesenchymal stem cell (MSC)-derived small extracellular vesicles (sEVs), which play a critical role in immune system modulation and tissue regeneration.
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