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Internal transcribed spacer (ITS): The powerful DNA barcode and phylogenetic marker for successful authentication of Withania somnifera.
Mol Biol Rep
December 2024
R&D Healthcare Division, Emami Limited, 13 B.T Road, Belgharia, Kolkata, West Bengal, 700056, India.
Background: Understanding the evolutionary history of plants and accurately identifying biologically important species and their families is crucial for the herbal and Ayurvedic industries. The genetic approach by DNA barcoding plays a pivotal role in accurate species identification, authentication and quality control. Due to various therapeutic properties, Withania somnifera has been used worldwide in traditional systems of medicine for centuries including Ayurveda and Unani.
View Article and Find Full Text PDFPrevalence and co-occurrence of cognitive impairment in children and young people up to 12-months post infection with SARS-CoV-2 (Omicron variant).
Brain Behav Immun
July 2024
Division of Surgery & Interventional Science, Faculty of Medical Sciences, University College London, WC1E 6BT, The United Kingdom of Great Britain and Northern Ireland. Electronic address:
Article Synopsis
- Cognitive impairment, referred to as "brain fog," was reported in 7.0% of first-time PCR-positive children and young people (CYP) and 7.5% of reinfected CYP 12 months after SARS-CoV-2 infection, indicating no significant difference by infection status.
- Most cases of cognitive impairment either appeared at the time of testing or within three months post-test, with similar prevalence observed across both groups.
- A majority of those with cognitive issues were aged 15 to 17, suggesting a potential age-related trend in the manifestation of cognitive impairments related to the infection.
Dihydroartemisinin ameliorated the inflammatory response and regulated miRNA-mRNA expression profile of chronic nonbacterial prostatitis.
Adv Clin Exp Med
August 2024
Department of Urology, Hebei Province Hospital of Chinese Medicine, Shijiazhuang, China.
Article Synopsis
- - Chronic nonbacterial prostatitis (CNP) causes painful and frequent urination, significantly impacting the quality of life, and the role of dihydroartemisinin (DHA) in treating CNP is not fully understood.
- - In a study using a mouse model for CNP, DHA was found to reduce prostate tissue damage, alleviate pain, and decrease inflammation markers, while also affecting microRNA expression.
- - The findings suggest that DHA helps improve CNP by regulating specific miRNAs and signaling pathways related to inflammation and tissue damage.
Unsolved mystery of Fas: mononuclear cells may have trouble dying in patients with Sjögren's syndrome.
BMC Immunol
June 2023
Department of Dentistry, Faculty of Medicine in Hradec Kralove, Charles University and University Hospital, Sokolska 581, 500 05, Hradec Kralove, Czech Republic.
Background: Patients with Sjögren's syndrome, like other patients with autoimmune disorders, display dysregulation in the function of their immune system. Fas and Fas Ligand (FasL) are among the dysregulated proteins.
Methods: We studied Fas and FasL on IL-2Rα cells and in serum of patients with Sjögren's syndrome (n = 16) and healthy individuals (n = 16); both from same ethnic and geographical background.
TET2 Promotes Keloid Hyperplasia by Regulating 5hmC Modification in the TGFβ Promoter Region.
Clin Cosmet Investig Dermatol
April 2023
Plastic Surgery, Affiliated Hospital of Weifang Medical University, Weifang, People's Republic of China.
Introduction: As a kind of human unique benign skin tumour, keloid has caused great trouble to the physical and mental health of patients and is unfavourable for beautiful. The abnormal proliferation of fibroblasts is one of the main causes of keloid formation. TET2 (Ten eleven translocation 2) catalyzes the oxidation of cytosine 5mC to 5hmC which process plays important role in cell proliferation.
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