In the framework of the IFMIF-EVEDA project (International Fusion Materials Irradiation Facility-Engineering Validation and Engineering Design Activities), CEA∕IRFU is in charge of the design, construction, and characterization of the 140 mA continuous deuteron injector, including the source and the low energy beam line. The electron cyclotron resonance ion source which operates at 2.45 GHz is associated with a 4-electrode extraction system in order to minimize beam divergence at the source exit. Krypton gas injection is foreseen in the 2-solenoid low energy beam line. Such Kr injection will allow reaching a high level of space charge compensation in order to improve the beam matching at the radio frequency quadrupole (RFQ) entrance. The injector construction is now completed on the Saclay site and the first plasma and beam production has been produced in May 2011. This installation will be tested with proton and deuteron beams either in pulsed or continuous mode at Saclay before shipping to Japan. In this paper, after a brief description of the installation, the preliminary results obtained with hydrogen gas injection into the plasma chamber will be reported.
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http://dx.doi.org/10.1063/1.3673643 | DOI Listing |
Commun Biol
January 2025
CIRI, Centre International de Recherche en Infectiologie, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Lyon, France.
We have assessed antiviral activity and induction of protective immunity of fusion-inhibitory lipopeptides derived from the C-terminal heptad-repeat domain of SARS-CoV-2 spike glycoprotein in transgenic mice expressing human ACE2 (K18-hACE2). The lipopeptides block SARS-CoV-2 infection in cell lines and lung-derived organotypic cultures. Intranasal administration in mice allows the maintenance of homeostatic transcriptomic immune profile in lungs, prevents body-weight loss, decreases viral load and shedding, and protects mice from death caused by SARS-CoV-2 variants.
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January 2025
College of Intelligence and Computing, Tianjin University, Tianjin, 300000, China.
Falling is an emergency situation that can result in serious injury or even death, especially in the absence of immediate assistance. Therefore, developing a model that can accurately and promptly detect falls is crucial for enhancing quality of life and safety. In the field of object detection, while YOLOv8 has recently made notable strides in detection accuracy and speed, it still faces challenges in detecting falls due to variations in lighting, occlusions, and complex human postures.
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January 2025
Department of Orthopedic Surgery, Beijing Chao-Yang Hospital, Capital Medical University, GongTiNanLu 8#, Chaoyang District, Beijing, 100020, China.
We aimed to analyze the cervical sagittal alignment change following the growing rod treatment in early-onset scoliosis (EOS) and identify the risk factors of sagittal cervical imbalance after growing-rod surgery of machine learning. EOS patients from our centre between 2007 and 2019 were retrospectively reviewed. Radiographic parameters include the cervical lordosis (CL), T1 slope, C2-C7 sagittal vertical axis (C2-7 SVA), primary curve Cobb angle, thoracic kyphosis (TK), C7-S1 sagittal vertical axis (C7-S1 SVA) and proximal junctional angle (PJA) were evaluated preoperatively, postoperatively and at the final follow-up.
View Article and Find Full Text PDFComput Methods Programs Biomed
January 2025
Guizhou Province International Science and Technology Cooperation Base for Precision Imaging Diagnosis and Treatment, Key Laboratory of Advanced Medical Imaging and Intelligent Computing of Guizhou Province, Department of Radiology, Guizhou Provincial People's Hospital, Guizhou 550002, China. Electronic address:
Background And Objective: Accurate segmentation of the prostate region in magnetic resonance imaging (MRI) is crucial for prostate-related diagnoses. Recent studies have incorporated Transformers into prostate region segmentation to better capture long-range global feature representations. However, due to the computational complexity of Transformers, these studies have been limited to processing single slices.
View Article and Find Full Text PDFJ Hazard Mater
January 2025
State Key Laboratory of Food Science and Resources, Nanchang University, No. 235 Nanjing East Road, Nanchang 330047, China; Sino-German Joint Research Institute, Nanchang University, No. 235 Nanjing East Road, Nanchang 330047, China; In Vitro Diagnostic Technology Innovation Center for Nanobody, No. 1166 Yiyuan Road, Nanchang, Jiangxi Province 330038, China; International Institute of Food Innovation Co., Ltd., Nanchang University, Luozhu Road, Nanchang 330200, China. Electronic address:
Lateral flow immunoassays (LFAs) are widely used in point-of-care testing (POCT) for detecting small molecules. However, their application is often hindered by the complex synthesis of traditional chemically synthesized antigens. Nanobody-based coating antigen mimics have shown excellent analytical performance in various immunoassay platforms, but their application in LFAs still faces challenges.
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