AI Article Synopsis
- The standard soybean oil-based intravenous fat emulsions (IVFEs) currently meet the nutritional needs of most patients, but there are alternative options such as medium-chain triglycerides, olive oils, and fish oils that have been used safely in Europe.
- These alternatives may offer benefits like reduced inflammation and immune suppression due to different metabolic pathways compared to soybean oil.
- Further research is essential to determine the most effective oil compositions for patients who might benefit from reduced intake of proinflammatory fatty acids.
Article Abstract
The currently available, standard soybean oil (SO)-based intravenous fat emulsions (IVFEs) meet the needs of most parenteral nutrition (PN) patients. There are alternative oil-based fat emulsions, such as medium-chain triglycerides (MCTs), olive oils (OOs), and fish oils (FOs), that, based on extensive usage in Europe, have an equivalent safety profile to SO. These alternative IVFEs are metabolized via different pathways, which may lead to less proinflammatory effects and less immune suppression. These alternative oil-based IVFEs are not currently available in the United States. Many patients who require IVFEs are already in a compromised state. Such patients could potentially have better clinical outcomes when receiving one of the alternative IVFEs to diminish the intake of the potentially proinflammatory ω-6 fatty acid-linoleic acid-which comprises more than 50% of the fatty acid profile in SO. Further research is needed on these alternative oil-based IVFEs to identify which IVFE oils or which combination of oils may be most clinically useful for specific patient populations.
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| http://dx.doi.org/10.1177/0884533612439896 | DOI Listing |
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