In vitro anti-allergic screening of medicinal herbal extracts revealed that the EtOAc extract of the rhizoma of Kadsura coccinea inhibited nitric oxide (NO) production in a lipopolysaccharide and recombinant mouse interferon-γ activated murine macrophage-like cell line, RAW264.7. Further fractionation of the EtOAc extract led to the isolation of two new dibenzocyclooctadiene lignans kadsuralignan G (1) and kadsuralignan L (2), and three known analog compounds. The absolute stereostructures were established by circular dichroism spectra. Both 1 and 2 showed moderate NO production inhibitory activities.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/10286020.2011.654334 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Schisandrin a Ameliorates Cardiac Injury and Dysfunction Induced by Hemorrhagic Shock via Activating the Nrf2 Signaling Pathway.
Am J Chin Med
December 2024
Department of Emergency and Critical Care Medicine, Wuxi 9th People's Hospital, Affiliated to Soochow University, Wuxi, Jiangsu 214000, P. R. China.
Hemorrhagic shock (HS) is a critical condition with high mortality caused by acute blood loss. Cardiac injury and dysfunction induced by HS is a major factor associated with the poor prognosis of affected patients. Schisandrin A (Sch A), a dibenzocyclooctadiene lignan extracted from , exhibits multiple biological activities, including anti-inflammatory, and antioxidant effects.
View Article and Find Full Text PDFPhytochemical Profiling and Biological Activities of Extracts from Bioreactor-Grown Suspension Cell Cultures of .
Molecules
November 2024
Department of Medicinal Plant and Mushroom Biotechnology, Jagiellonian University, Medical College, ul. Medyczna 9, 30-688 Kraków, Poland.
Plant biotechnology creates opportunities for the cultivation of plants regardless of their natural habitats, which are often protected or difficult to access. Maintaining suspension cell cultures in bioreactors is an advanced part of biotechnological research that provides possibilities for obtaining plant tissue on a large scale. In this study, the suspension culture cultivation of a Chinese endemic plant, , in a stirred tank bioreactor was elaborated for the first time.
View Article and Find Full Text PDFHepatoprotective dibenzocyclooctadiene lignans from the fruits of Kadsura coccinea.
Fitoterapia
October 2024
School of Pharmaceutical Sciences, Hunan University of Medicine, Huaihua 418000, China; School of Pharmaceutical Science, University of South China, Hengyang 421001, Hunan Province, China. Electronic address:
The phytochemical investigations on the fruits of Kadsura coccinea led to the isolation of six undescribed dibenzocyclooctadiene lignans named kadcolignans B-G, together with eleven previously described analogues. The structures of these compounds were established by spectroscopic methods including NMR, HRESIMS, and CD experiments. All isolated compounds were evaluated for their hepatoprotective activity by measuring the levels of triglyceride (TG), total cholesterol (TC), and reactive oxygen species (ROS) in FFA-induced HepG2 cells.
View Article and Find Full Text PDFTracking Chlamydia - Host interactions and antichlamydial activity in Caenorhabditis elegans.
Biomed Pharmacother
August 2024
Drug Research Program, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Helsinki 00014, Finland. Electronic address:
The fading efficacy of antibiotics is a growing global health concern due to its life-threatening consequences and increased healthcare costs. Non-genetic mechanisms of antimicrobial resistance, such as those employed by Chlamydia pneumoniae and Chlamydia trachomatis, complicate treatment as these bacteria can enter a non-replicative, persistent state under stress, evading antibiotics and linking to inflammatory conditions. Understanding chlamydial persistence at the molecular level is challenging, and new models for studying Chlamydia-host interactions in vivo are urgently needed.
View Article and Find Full Text PDFComparative Assessment of Lignan Profiling and Biological Activities of Leaf and In Vitro PlantForm Bioreactor-Grown Culture Extracts.
Pharmaceuticals (Basel)
March 2024
Department of Pharmaceutical Botany, Medical College, Jagiellonian University, Medyczna 9 str., 30-688 Kraków, Poland.
This research's scope encompassed biotechnological, phytochemical, and biological studies of , including investigations into its in vitro microshoot culture grown in PlantForm bioreactors (temporary immersion systems, TISs), as well as extracts from leaves of the parent plant, focusing on anti-inflammatory, antioxidant, anticancer, and antimicrobial activities. The phytochemical analysis included the isolation and quantification of 17 compounds from dibenzocyclooctadiene, aryltetralin lignans, and neolignans using centrifugal partition chromatography (CPC), HPLC-DAD, and UHPLC-MS/MS tandem mass spectrometry with triple quadrupole mass filter methods. Higher contents of compounds were found in microshoots extracts (max.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!