Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3284931 | PMC |
| http://dx.doi.org/10.1186/1753-6561-5-S8-P28 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The TOXIN knowledge graph: supporting animal-free risk assessment of cosmetics.
Database (Oxford)
January 2025
Department of In Vitro Toxicology and Dermato-Cosmetology (IVTD), Vrije Universiteit Brussel, Laarbeeklaan 103, Brussels 1090, Belgium.
The European Union's ban on animal testing for cosmetic products and their ingredients, combined with the lack of validated animal-free methods, poses challenges in evaluating their potential repeated-dose organ toxicity. To address this, innovative strategies like Next-Generation Risk Assessment (NGRA) are being explored, integrating historical animal data with new mechanistic insights from non-animal New Approach Methodologies (NAMs). This paper introduces the TOXIN knowledge graph (TOXIN KG), a tool designed to retrieve toxicological information on cosmetic ingredients, with a focus on liver-related data.
View Article and Find Full Text PDFTime-varying reproduction number estimation: fusing compartmental models with generalized additive models.
J R Soc Interface
January 2025
Department of Mathematics, The University of Manchester, Manchester, UK.
The reproduction number, the mean number of secondary cases infected by each primary case, gives an indication of the effort required to control the disease. Beyond the well-known reproduction number, there are two natural extensions, namely the and reproduction numbers. As behaviour, population immunity and viral characteristics can change with time, these reproduction numbers can vary over time.
View Article and Find Full Text PDFLight-Driven Regioselective Deoxygenation of Carbohydrate Lactones for 2-Deoxy Sugar Precursor Synthesis.
Org Lett
January 2025
Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw 01-224, Poland.
A sustainable method for the synthesis of 2-deoxy lactones as direct precursors to 2-deoxy sugars via regioselective UV-light-driven dealkyloxylation of carbohydrate-derived lactones is detailed. This catalyst- and additive-free protocol utilizes light irradiation, providing high step economy and functional group compatibility. This environmentally friendly and straightforward approach enhances the synthetic toolbox for 2-deoxy sugars, which is vital in numerous biologically active molecules and drug candidates.
View Article and Find Full Text PDFPhysioEx, a new Python library for explainable sleep staging through deep learning.
Physiol Meas
January 2025
Department of Electrical Engineering, KU Leuven, Kasteelpark Arenberg 10 postbus 2440 3001 LEUVEN Belgium, Leuven, Flanders, 3000, BELGIUM.
Sleep staging is a crucial task in clinical and research contexts for diagnosing and understanding sleep disorders. This work introduces PhysioEx, a Python library designed to support the analysis of sleep stages using deep learning and Explainable AI (XAI). Approach: PhysioEx provides an extensible and modular API for standardizing and automating the sleep staging pipeline, covering data preprocessing, model training, testing, fine-tuning, and explainability.
View Article and Find Full Text PDFVisible-light-promoted cascade cyclization of -arylacrylamides with bromomethyl sulfone: access to sulfonylmethylated phenanthridines.
Org Biomol Chem
January 2025
Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Green Catalysis Center, and College of Chemistry, Zhengzhou University, Zhengzhou 450052, China.
We present a visible-light-promoted radical cascade cyclization reaction sulfonylmethylation, cyano insertion, and radical cyclization of unactivated alkenes bearing cyano groups. This strategy enables the rapid synthesis of sulfonylmethylated phenanthridines under mild conditions with broad substrate compatibility, operational simplicity, and mild reaction conditions. The developed approach provides a novel pathway for assembling complex polycyclic nitrogen-containing frameworks, addressing a critical synthetic challenge and expanding the toolbox of photochemical transformations in organic synthesis.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!