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Periprostatic adipose tissue inhibits tumor progression by secreting apoptotic factors: A natural barrier induced by the immune response during the early stages of prostate cancer.
Oncol Lett
October 2024
Division of Urology, Department of Surgery, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 333423, Taiwan, R.O.C.
Article Synopsis
- * This study explored the link between pelvic adipose tissue (fat) and the severity of PCa by analyzing tissue samples from 50 patients who underwent prostate surgery, examining the impact of periprostatic adipose tissue (PPAT) on cancer cell behavior.
- * Findings showed that higher levels of PPAT and pelvic fat correlated with worse PCa aggressiveness and that PPAT-conditioned medium reduced the growth of certain PCa cell lines, highlighting the potential role of fat tissue in modulating cancer behavior
Tumoral periprostatic adipose tissue exovesicles-derived miR-20a-5p regulates prostate cancer cell proliferation and inflammation through the RORA gene.
J Transl Med
July 2024
Disease Biomarkers and Molecular Mechanisms Group. IISPV. Joan, XXIII University Hospital, Universitat Rovira i Virgili, Tarragona, Spain.
Background: From the first steps of prostate cancer (PCa) initiation, tumours are in contact with the most-proximal adipose tissue called periprostatic adipose tissue (PPAT). Extracellular vesicles are important carriers of non-coding RNA such as miRNAs that are crucial for cellular communication. The secretion of extracellular vesicles by PPAT may play a key role in the interactions between adipocytes and tumour.
View Article and Find Full Text PDFMeasurements of peri-prostatic adipose tissue by MRI predict bone metastasis in patients with newly diagnosed prostate cancer.
Front Oncol
April 2024
Department of Urology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Objectives: To investigate the role of MRI measurements of peri-prostatic adipose tissue (PPAT) in predicting bone metastasis (BM) in patients with newly diagnosed prostate cancer (PCa).
Methods: We performed a retrospective study on 156 patients newly diagnosed with PCa by prostate biopsy between October 2010 and November 2022. Clinicopathologic characteristics were collected.
Elevated periprostatic androgens, sneaky testosterone and its implications.
Nat Rev Urol
December 2024
Desai Sethi Urology Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
A subset of men with prostate cancer have elevated periprostatic androgens compared with levels in peripheral blood (termed the sneaky T phenomenon), which are associated with poor clinical outcomes after radical prostatectomy. These androgens are of testicular origin and reach the prostate, presumably through venous shunting. Varicocele physiology is accompanied by increased hydrostatic pressure within the pelvic venous system, providing a theoretical mechanistic explanation for the sneaky T phenomenon.
View Article and Find Full Text PDFBackground: Schwannomas originating in the prostate are extremely rare. We present a case of prostatic schwannoma in a 66-year-old male with lower urinary tract symptoms. Preoperative evaluation revealed a prostatic mass, and the definitive diagnosis was made through laparoscopic radical prostatectomy.
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