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Hypoglycaemia: a little known effect of Venlafaxine overdose. | LitMetric

Hypoglycaemia: a little known effect of Venlafaxine overdose.

Clin Toxicol (Phila)

CHRU de Tours, Réanimation Médicale, 2 Boulevard Tonnellé, Tours Cedex 9, France.

Published: March 2012

AI Article Synopsis

  • A 39-year-old woman had serious health problems because she took too much of a medicine called venlafaxine, leading to issues like serotonin syndrome and low blood sugar (hypoglycemia).
  • Doctors tried giving her sugar in liquid form to help her blood sugar, but it kept dropping again.
  • Finally, they gave her a special injection called octreotide, which helped bring her blood sugar back to normal and stopped the need for sugar drinks.

Article Abstract

We report the case of a 39-year-old woman who presented with serotonin syndrome and hypoglycaemia likely due to intoxication with a very high dose of venlafaxine. This case of venlafaxine-associated hypoglycaemia was treated first by glucose perfusion, but despite large doses, hypoglycaemia recurred. Blood glucose normalized after injection of octreotide, eliminating the need for hypertonic glucose. Octreotide has been shown to decrease glucose requirements and the number of hypoglycaemic episodes in patients with sulfonylurea-induced hypoglycaemia but, to our knowledge, its ability to resolve hypoglycaemic episodes due to massive venlafaxine overdose has not yet been described.

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Source
http://dx.doi.org/10.3109/15563650.2012.660696DOI Listing

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