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Enhanced platelet-derived microparticle formation is associated with carotid atherosclerosis in convalescent stroke patients. | LitMetric

AI Article Synopsis

  • Platelets are involved in atherosclerosis by interacting with cells in blood vessels, leading researchers to study the link between platelet activity and carotid atherosclerosis in stroke patients and controls.* -
  • In a study with 94 stroke patients and 76 controls, higher carotid intima-media thickness (IMT) was found in stroke patients, along with increased levels of platelet-derived microparticles (PMPs), indicating greater platelet activity.* -
  • The analysis revealed that more PMPs correlated positively with carotid thickening and stroke occurrence, while lower activation of platelet receptors was linked to increased IMT and atherosclerotic plaque, suggesting potential biomarkers for cardiovascular issues.*

Article Abstract

Platelets participate in the development and progression of atherosclerosis. During this process they interact with endothelial cells and leukocytes. Therefore, we investigated the associations between carotid atherosclerosis and platelet reactivity markers. The platelet surface expression of P-selectin (CD62P) and the activated GPIIb/IIIa receptor (corresponding to increased binding of PAC-1), as well as the fraction of platelet-derived microparticles (PMPs) prior to and after platelet stimulation with TRAP or ADP, were determined using flow cytometry in 94 subjects in the convalescent phase of ischaemic stroke and in 76 disease controls. The mean common carotid intima-media thickness (CCA(mean) IMT), maximal common carotid IMT (CCA(max) IMT) and maximal bifurcation IMT (BIF(max) IMT) were measured bilaterally using B mode, colour Doppler ultrasonography. In stroke subjects IMT within CCA and BIF were greater than in disease controls and the percentage of PMPs prior to and after ex vivo stimulation with agonists was significantly higher than in controls. Multiple regression analysis revealed that PMPs were positively and independently correlated with both CCA(mean) IMT (β = 0.23; p < 0.01) and stroke (β = 0.21; p<0.01), while PAC-1 binding to platelets activated with ADP was negatively and independently associated with CCA(mean) IMT (β = -0.29; p<0.001) and atherosclerotic carotid plaque presence (β = -0.28, p = 0.003). We found a positive association between enhanced PMP formation and atherosclerotic thickening of carotid intima-media or carotid plaque in patients after ischaemic stroke. We demonstrated that diminished expression of active GPIIb/IIIa in the ADP-activated platelets is associated with increased carotid IMT, independently of stroke.

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Source
http://dx.doi.org/10.3109/09537104.2011.654292DOI Listing

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