Three indole alkaloids that possess differing degrees of psychotropic/psychedelic activity have been reported as endogenous substances in humans; N,N-dimethyltryptamine (DMT), 5-hydroxy-DMT (bufotenine, HDMT), and 5-methoxy-DMT (MDMT). We have undertaken a critical review of 69 published studies reporting the detection or detection and quantitation of these compounds in human body fluids. In reviewing this literature, we address the methods applied and the criteria used in the determination of the presence of DMT, MDMT, and HDMT. The review provides a historical perspective of the research conducted from 1955 to 2010, summarizing the findings for the individual compounds in blood, urine, and/or cerebrospinal fluid. A critique of the data is offered that addresses the strengths and weaknesses of the methods and approaches to date. The review also discusses the shortcomings of the existing data in light of more recent findings and how these may be overcome. Suggestions for the future directions of endogenous psychedelics research are offered.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/dta.422 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Unlocking Platelet Mechanisms through Multi-Omics Integration: A Brief Review.
Curr Cardiol Rev
January 2025
Laboratory of Chemoinformatics, Infochemistry Scientific Center, ITMO University, Saint-Petersburg, Russian Federation.
Platelets, tiny cell fragments measuring 2-4 μm in diameter without a nucleus, play a crucial role in blood clotting and maintaining vascular integrity. Abnormalities in platelets, whether genetic or acquired, are linked to bleeding disorders, increased risk of blood clots, and cardiovascular diseases. Advanced proteomic techniques offer profound insights into the roles of platelets in hemostasis and their involvement in processes such as inflammation, metastasis, and thrombosis.
View Article and Find Full Text PDFA Menu for Microbes: Unraveling Appetite Regulation and Weight Dynamics Through the Microbiota-Brain Connection Across the Lifespan.
Am J Physiol Gastrointest Liver Physiol
January 2025
Metabolism and Nutrition Department. NOVA Medical School, Faculdade de Ciências Médicas, NMS, FCM, Universidade NOVA de Lisboa. Lisbon, Portugal.
Appetite, as the internal drive for food intake, is often dysregulated in a broad spectrum of conditions associated with over- and under-nutrition across the lifespan. Appetite regulation is a complex, integrative process comprising psychological and behavioral events, peripheral and metabolic inputs, and central neurotransmitter and metabolic interactions. The microbiota-gut-brain axis has emerged as a critical mediator of multiple physiological processes, including energy metabolism, brain function, and behavior.
View Article and Find Full Text PDFMycotoxin management in Sub-Saharan Africa: A comprehensive systematic review of policies and strategies in Malawi.
Toxicol Rep
June 2025
Browns Consulting Company PO Box 274, Rumphi, Malawi.
Food safety challenges, such as mycotoxin contamination, pose severe threats to public health, agricultural productivity, and economic development across Sub-Saharan African countries and beyond. This study investigated whether government policies related to food safety adequately address these concerns, using Malawi as a case study. We systematically reviewed 29 government-authored policy documents related to food safety.
View Article and Find Full Text PDFConnection between oral health and chronic diseases.
MedComm (2020)
January 2025
State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Conservative Dentistry and Endodontics, West China Hospital of Stomatology Sichuan University Chengdu Sichuan China.
Chronic diseases have emerged as a paramount global health burden, accounting for 74% of global mortality and causing substantial economic losses. The oral cavity serves as a critical indicator of overall health and is inextricably linked to chronic disorders. Neglecting oral health can exacerbate localized pathologies and accelerate the progression of chronic conditions, whereas effective management has the potential to reduce their incidence and mortality.
View Article and Find Full Text PDFEvaluation of predictions of disordered binding regions in the CAID2 experiment.
Comput Struct Biotechnol J
December 2024
Department of Computer Science, Virginia Commonwealth University, Richmond, VA 23284, USA.
A large portion of the Intrinsically Disordered Regions (IDRs) in protein sequences interact with proteins, nucleic acids, and other types of ligands. Correspondingly, dozens of sequence-based predictors of binding IDRs were developed. A recently completed second community-based Critical Assessments of protein Intrinsic Disorder prediction (CAID2) evaluated 32 predictors of binding IDRs.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!