Purpose: The GNAS1 gene is linked to proapoptotic signaling and correlates closely with clinical outcomes in many human cancers. The aim of this study was to evaluate whether the T393C polymorphism of the GNAS1 gene could be used as a chemotherapy sensitivity and prognosis predictive marker of advanced non-small-cell lung cancer (NSCLC) treated with gemcitabine plus platinum (GP).
Methods: In this study, we performed the PCR-restriction fragment length polymorphism assay to examine the genotypes of the GNAS1 T393C polymorphism in 131 peripheral blood DNA specimens from advanced NSCLC patients with GP treatment.
Results: The frequencies of the CC, CT, and TT genotypes in 131 advanced NSCLC cases were 25.2, 47.4, and 26.7%, respectively. The favorable TT genotype was significantly correlated with better overall survival (OS; P < 0.05) and longer progress-free survival (PFS; P < 0.05) compared with the CT or CC genotype. In the multivariate Cox proportional hazards model, the GNAS1 T393C polymorphism was independently associated with overall survival after adjusting the clinicopathological factors (P < 0.05).
Conclusions: This study suggests that the TT genotype of the GNAS1 T393C polymorphism could be an independent prognostic marker to predict chemotherapy sensitivity, favorable OS and PFS in advanced NSCLC patients with GP treatment.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00280-012-1849-3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The SNP c.393C>T (rs7121) as a marker for disease progression and survival in cancer.
Pharmacogenomics
May 2019
Institute of Pharmacogenetics, University Hospital Essen, University of Duisburg-Essen, Hufelandstr. 55, 45122 Essen, Germany.
G-protein receptor signaling plays a key role in multiple signal transduction pathways. Aberrant activity of the stimulatory Gα subunit has been frequently associated with cancer. sequence alterations and conformational changes of Gα can both enhance or diminish its function and change downstream effects of G-protein receptor signaling.
View Article and Find Full Text PDFAnalysis of the influence of the T393C polymorphism of the GNAS gene on the clinical expression of primary hyperparathyroidism.
Endocrinol Diabetes Nutr
December 2017
Servicio de Endocrinología, Hospital Universitario "Marqués de Valdecilla", Instituto de Investigación "Marqués de Valdecilla" (IDIVAL), Universidad de Cantabria, Avda. de Valdecilla s/n, Santander 39008, Cantabria, Spain.
Background: The receptor of parathyroid hormone and parathyroid hormone-related-protein (PTH/PTHrp) is located in the cell membrane of target tissues - kidney and osteoblasts. It is a G protein-coupled-receptor whose Gα subunit is encoded by the GNAS gene. Our aim was to study whether the single nucleotide polymorphism (SNP) T393C of the GNAS gene is associated with renal stones, bone mineral density (BMD), or bone remodelling markers in primary hyperparathyroidism (PHPT).
View Article and Find Full Text PDFRelationship between GNAS1 T393C polymorphism and aseptic loosening after total hip arthroplasty.
Eur J Med Res
August 2017
Institute of Pharmacogenetics, University Hospital Essen, 45147, Essen, Germany.
Background: Aseptic loosening is a main cause for revision surgery after total hip arthroplasty (THA) and there is no reliable marker for the early detection of patients at high risk. This study has been performed to validate association of the T393C polymorphism (rs7121) in the GNAS1 gene, encoding for the alpha-subunit of heterotrimeric G-protein Gs, with risk for and time to aseptic loosening after THA, which has been demonstrated in our previous study.
Methods: 231 patients with primary THA and 234 patients suffering from aseptic loosening were genotyped for dependency on GNAS1 genotypes and analyzed.
[Genetic dependency of blood pressure and heart rate in patients with arterial hypertension and obesity].
Vestn Ross Akad Med Nauk
February 2015
Background: The aim of the study was to determine the effect of gene polymorphisms Arg389Gly ADRβ1 gene and T393C gene GNAS1 on the level of heart rate (HR), systolic and diastolic blood pressure (SBP and DBP) in hypertensive patients according to body mass index (BMI).
Patients And Methods: The study involved 166 patients with hypertension and 90 healthy individuals. Patients of the main group was divided according to BMI into three subgroups: I subgroup--with normal body weight, II subgroup--overweight, II subgroup--obesity.
TT genotype of GNAS1 T393C polymorphism predicts better outcome of advanced non-small cell lung cancer patients.
World J Gastrointest Oncol
December 2014
Hong-Yun Gong, Wei-Guo Hu, Qin-Bin Song, Department of Oncology, Renmin Hospital of Wuhan University, Wuhan 430060, Hebei Province, China.
Article Synopsis
- The study aimed to assess the impact of the GNAS1 T393C polymorphism on prognosis in patients with advanced non-small cell lung cancer.
- Genomic DNA from 94 patients was analyzed, revealing that those with the TT genotype had a significantly longer median survival (25 months) compared to CT (12 months) and CC (8 months) genotypes.
- The findings suggested that the TT genotype is associated with better overall survival rates, highlighting the importance of genetic factors in predicting outcomes for lung cancer patients.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!